Anti-Inflammatory And Anti-Nociceptive Effects Of The Methanol Root Extract Of Maniophyton fulvum Muell Arg. (Eupherbiaceae) In Albino Mice
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Abstract
Maniophyton fulvum is a herbaceous plant used in Akwa Ibom State, Nigeria to treat pains, frequent stooling and swellings. In this study, the methanol root extract of the plant was investigated for its phytochemical constituents, safety profile, anti-inflammatory and anti-nociceptive properties. The result of the phytochemical screening revealed that the plant contained flavonoids and terpenes. The median Lethal Dose (LD50) was 948.68 mg/kg. At a dose of 284.60 mg/kg the extract exhibited a significant (p<0.05) anti-inflammatory effect against oedema induced by egg-albumin and xylene. The dose also exhibited a significant (p<0.05) anti-nociceptive effect against acetic acid-induced writhing movement and formalin-induced hind paw licking in mice. The presence of flavonoids and terpenes in the plant is believed to cause the reduction in the inflammation and pain in the mice.
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References
Akah, P. A, and Nwanibe, A., (1994). Evaluation of Nigerian Traditional Medicine I. Plants used in Rheumatic (Inflammatory) Disorders. J. Ethnopharmacol, 42: 179-182.
Amico-Roxas, M., Caruso A., Trombadore, S., Scifo R., and Scapagnme, U. (1984). Gangliosides Antinociceptive Effects in Rodents. Achieves of International Pharmacodynamics and Therapeutics 272: 103-117.
Burkill, H. M. (1994). The useful Plants of West Tropical Africa, 2nd Edition. Royal Botanic Gardens, Kew, Richmond: United Kingdom, 636 p.
Carlo, D. G. Mascolo, N. Capasso, F. (1999).Flavonoids, Old and New Aspecys of a Class of Natural Therepeutic Drugs. Life Science 65:337-353.
Essien, E. E. Nia, R. Paper, D. H., Franz, Muguanza, M. and Hohmann, G. (2005).“Antioxidant and Anti-Inflammatory Activity of Manniophyton fulvum”. Act Horticulture 678:97-101.
Harper D, (2001). Online Enzymology Dictionary. Analgesia Retrieved. 102-108
Lorke, D. (1983). A New Approach to Practical Acute Toxicity Test. Arch Toxicol 54: 393-404.
Mbagwu, H. O. C., Anene, R. A., and Adeyemi O. O. (2007). Analgesic, Antipyretic and Anti-Inflammatory Properties of Mezoneuron benthamianum Bail Caesalpiniaccea. .Nigeria quarterly Journal of hospital medicine. 17 (1): 35-41.
Nwafor, P. A. Jacks, T. W., and Ekanem, A. U. (2007). Analgesic and Anti-Inflammatory effect of methanolic extract of Pavsinystalia mecroceras stem bark in rodents. Journal of pharmacology 3: 86-90.
Okokon, J. E., and Nwafor, P. A. (2010). Anti-Inflammatory, analgesic and antipyretic activities of ethanolic root extract of Croton zambesicus”. Pakistan Journal of Pharmaceutical Sciences.23 (4): 383:390.
Okoli, I. C. Ebere, C. S. Uchegbu, M. C., Udah, A. and Ibeawuchi, I. I., (2003). A Survey of the Diversity of Plants Utilized for Small Ruminant Feeding in South-Eastern Nigeria. Agriculture, Ecosystems and Environment 96 (1-3): 147:154.
Sofowora, E. A. (1993). Medicinal Plants and Traditional Medicine in Africa, 2nd Edition. Spectrum Books Limited, Ibadan, Nigeria, pp. 1-88.
Trease, G. E., and Evans, W. C. (2002). Pharmacognosy; London.BailliereTindall: 220-253, 401-404; 527-534.
Usifoh Cyril, Udobre Aniefiok, Isang Mandu and Essien Grace (2016). Phytochemcial and some Biological Activities of the stem Bark Extract of Pentaclethra macrophylla Benth. European Journal of Biomedical and Pharmaceutical Sciences, India 3 (9) 538-541.
Yi Yl, Zong HA, Lu Zm, XuHy Zhang Xm, Dou Wf and Xu ZH (2008). Analgesic and Antiinflammatory effects of the dry matter of culture broth of Termitomyces albuminosus and its extracts. Journal of Ethnopharmacology 120: 432-436.