Formulation of Mucoadhesive Tablets of Metronidazole using Irvingia gabonesis Gum

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Ajibade O. Ganiyat
Collins Airemwen
Johnbull A. Obarisiagbon
Catherine D. Soni-Osayande
Michael U. Uhumwangho

Résumé

Background: The aim of this study was to formulate mucoadhesive tablets of metronidazole using admixtures of HPMC and irvingia gum (IG) which was extracted from the seeds of Irvingia gabonensis (Irvingiaceae).


 


Methods: Various batches of metronidazole granules were prepared by wet granulation technique with the extracted irvingia gum at varying concentrations of 25-50%w/w. The granules were then compressed to tablets at a compression pressure of 25 N/m2. The tablets were evaluated for hardness, friability, bioadhesive strength, in vitro dissolution studies and release kinetics.


 


Results: All the formulated granules were free flowing with angle of repose between 25.4 and 29.6? and Carr’s index of ? 12.5%. The granules were compressible with hardness of 5.0 - 7.0 Kpa and friability of ? 0.67%, while the bioadhesive force was between 0.31 -1.31 N. The percent maximum release (m?) and time to achieve it (t?) for all the mucoadhesive tablets were ?97.2% at 10 h respectively. All batches fitted well into the Higuchi model release. The release mechanism showed non-fickian diffusion with 0.45<n<0.89.


 


Conclusion: Irvingia gum exhibited good mucoadhesive property retarding the release of metronidazole with maximum release of 88.8% at maximum time of 10 h.

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O. Ganiyat, A. ., Airemwen, C., A. Obarisiagbon, J. ., D. Soni-Osayande, C. ., & U. Uhumwangho, M. . (2020). Formulation of Mucoadhesive Tablets of Metronidazole using Irvingia gabonesis Gum . Nigerian Journal of Pharmaceutical and Applied Science Research, 9(4), 15–22. Consulté à l’adresse https://nijophasr.net/index.php/nijophasr/article/view/400
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Bibliographies de l'auteur-e

Ajibade O. Ganiyat

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin-City, Nigeria

Johnbull A. Obarisiagbon

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin-City, Nigeria

Catherine D. Soni-Osayande

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin-City, Nigeria

Michael U. Uhumwangho

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin-City, Nigeria

Références

Airemwen and Uhumwangho (2016). Formulation and evaluation of floating matrix tablets of metformin using acrylate methacrylate copolymer and Irvingia gabonesis gum. J. Pharm. and Allied Sci. 13 (1): 2331 – 2343.

Airemwen CO, Olarinoye AA and Uhumwangho MU (2020). Effect of sodium chloride as channeling agent on release profile of diclofenac tablets formulated using Grewia mollis and acacia gums. J. Pharm and Allied Sci. 17(1): 3203 – 3209.

Alalor CA, Uhumwangho MU and Iwuagwu MA (2018). Evaluation of Ciprofloxacin Floating-Bioadhesive Tablet Formulated with Okra Gum as Multifunctional Polymer, UK J Pharm and Biosciences 6(2): 01-11.

Amanpreet K, Priya M, Geeta A and Harikumar SL (2013). Mucoadhesive Drug Delivery System: A Review, Int. J. Drug Dev. and Res., 5 (1): 11-20.

Attama AA, Adikwu MU and Okoli ND (2000). Studies on bioadhesive granules: Granules formulated with Prosopsis africana (Prosopsis) gum. Chem and Pharm Bull, 48: 734-737.

Aulton ME and Wells TI (2008). Pharmaceutics: The Science of Dosage Form Design, London, England, Churchill Livingstone 1988, pp. 206-208.

Bharadia PD, Patel MM, Patel GC and Patel GN (2004). A preliminary investigation on sesbania gum as a pharmaceutical excipient. Int J Pharm Excipient. 3(1): 99-102.

Chawla G, Gupta P, Koradia V, Bansal A, (2003). Gastroretention: A Means to Address Regional Variability in Intestinal Drug Absorption. Pharm Tech, 27: 50-68.

Gandhi S, Pandya P, Umbarkar R, Tambawala T and Shah M (2011). Mucoadhesive Drug Delivery System- An Unusual Maneuver for Site Specific Drug Delivery System, Int J Pharm Sci., 2:132-152.

Goswami DS and Sharma M (2013). Preparation and Characterization of mucoadhesive tablets of amoxicillin using natural and synthetic polymers. J Applied Pharm Res 1(1): 22-25.

Hancock BC, Carlson GT, Ladipo DD, Langdon BA and Mullarney MP (2001). The powder flow and compact mechanical properties of two recently developed matrix forming polymers. J Pharm and Pharm; 53:1193–1199.

Higuchi T (1963). Mechanism of sustained action medication: Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci; 52, 1145-1149.

Korsmeyer RW, Gurny R, Doelker E, Buri P and Peppas NA (1983). Mechanisms of solute release from porous hydrophilic polymers. Int J Pharm, 15: 25 – 35.

Morkhade DM, Fulzele SV, Satturwar PM and Joshi SB (2006). Gum Copal and Gum Damar: Novel Matrix Forming Materials for Sustained Drug Delivery. Indian J Pharm Sci. 6: 53-58.

Odeku OA and Patani BO (2005). Evaluation of dika nut mucilage as a binding agent in metronidazole tablet formulations. Pharm Dev and Tech; 10 (3): 439-446.

:1193–1199.

Goswami DS and Sharma M. Preparation and Characterization of mucoadhesive tablets of amoxicillin using natural and synthetic polymers. J Applied Pharm Res (2013), 1(1): 22-25.