Formulation of Mucoadhesive Tablets of Metronidazole using Irvingia gabonesis Gum
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Background: The aim of this study was to formulate mucoadhesive tablets of metronidazole using admixtures of HPMC and irvingia gum (IG) which was extracted from the seeds of Irvingia gabonensis (Irvingiaceae).
Methods: Various batches of metronidazole granules were prepared by wet granulation technique with the extracted irvingia gum at varying concentrations of 25-50%w/w. The granules were then compressed to tablets at a compression pressure of 25 N/m2. The tablets were evaluated for hardness, friability, bioadhesive strength, in vitro dissolution studies and release kinetics.
Results: All the formulated granules were free flowing with angle of repose between 25.4 and 29.6? and Carr’s index of ? 12.5%. The granules were compressible with hardness of 5.0 - 7.0 Kpa and friability of ? 0.67%, while the bioadhesive force was between 0.31 -1.31 N. The percent maximum release (m?) and time to achieve it (t?) for all the mucoadhesive tablets were ?97.2% at 10 h respectively. All batches fitted well into the Higuchi model release. The release mechanism showed non-fickian diffusion with 0.45<n<0.89.
Conclusion: Irvingia gum exhibited good mucoadhesive property retarding the release of metronidazole with maximum release of 88.8% at maximum time of 10 h.
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