Bioactive constituents and antiulcer activity of the unripe fruit peel of Musa Paradisiaca L. (Musaceae)
Barre latérale de l'article
Contenu principal de l'article
Résumé
Background: Musa paradisiaca is used traditionally in treating diarrhoeal, wounds and infections and also in the management of diabetics and ulcer. This work aimed to evaluate the proximate contents, phytochemical constituents and the antiulcer potential of the peel of Musa paradisiaca.
Methods: Proximate parameters and phytochemical constituents was evaluated using standard procedures and gas chromatography-mass spectrometry (GC-MS), while the effect of the extract on ethanol induced stomach ulcer was study in adult Wister rats.
Results: Result revealed ash value (8.70 ± 0.50) %, crude fibre (10.50 ± 0.70) % and moisture content (20.30 ± 0.40) % respectively. Phytochemicals present included alkaloids, tannins, flavonoids, triterpenoids, steroids and saponins. GC-MS analysis identified twenty-three compounds including gamma tocopherol. The methanol extract exhibited significant antiulcer activity at 400 mg/kg and its activity increases as the dose increases.
Conclusion: The study showed that Musa paradisiaca contains important phytoconstituents and validated the ethno-medicinal claim of antiulcer effect.
Téléchargements
Renseignements sur l'article
Cette œuvre est sous licence Creative Commons Attribution - Pas d'Utilisation Commerciale - Pas de Modification 4.0 International.
Références
Nayar NM, The Bananas: Botany, Origin, Dispersal. Horticulture Review. 2010, 36, 117-164.
Oladiji AT, Idoko AS, Abodunrin TP, Yakubu MT. Studies on the physicochemical properties and fatty acid composition of the oil from ripe plantain peel (Musa paradisiaca). African Scientist, 11, 2010: (1) 73-78.
Philips TA, An Agricultural Notebook. Longman, Nigeria p.125.
Swennen R, Plantain cultivation under West African conditions: A reference manual, 1990b.
Oyeyinka BO, Afolayan AJ, Comparative Evaluation of the Nutritive, Mineral, and Antinutritive Composition of Musa sinensis L. (Banana) and Musa paradisiaca L. (Plantain) Fruit Compartments. Plants, 8, 2019, 598; doi:10.3390/plants8120598.
Tchobanoglous G, Theisen H, Vigil SA. Integrated solid waste management: Engineering principals and management issues. McGraw-Hill, New York, (1993). pp 3-22.
Ng SP, Fong CS, Banana enhances your anti-cancer power. In: Health discovery. Petaling Jaya Malalysia: Life Publisher Berhad. of cocoyam (Colocassia esculenta) leaf with some green leafy vegetables. Nigerian Journal of Nutritional Science, 27, 2000: (1) 22-26.
Okareh OT, Adeolu AT, Adepoju OT, Proximate and mineral composition of plantain (MusaParadisiaca) wastes flour; a potential nutrients source in the formulation of animal feeds. African Journal of Food Science and Technology, 6, 2015: (2) 53-57.
Ezekwesili CN, Ghasi, S., Adindu CS. Mefoh NC. Evaluation of the anti-ulcer property of aqueous extract of unripe Musa paradisiaca Linn. peel in Wistar rats. African Journal of Pharmacy and Pharmacology, 8, 2014: (39) 1006-1011.
Association of Official Analytical Chemists (AOAC), Official Methods of Analysis of Association of Analytical Chemists International, Kenneth Helrich. (ed). 15th edn. Vol I AOAC Inc., Virginia USA. Chapter. 4. 1990, p 84-87.
Sofowora A, Screening Plants for Bioactive Agents. In: Medicinal Plants and Traditional Medicinal in Africa. 2nd Ed.Spectrum Books Ltd, Sunshine House, Ibadan, Nigeria, (1993) p. 134-156.
GE. Trease, WC. Evans. Pharmacognosy. 15th Ed. Saunders Publishers, London. (2002).p. 42-44, 221-229, 246-249, 304-306, 331-332, 391-393.
Mbagwu H, Jackson C, Ekpo M, Okopedi E, Anah V, Ugwu C, Gastroprotective effects of ethanolic leaf extract of Musa paradisiaca L. (Musaceae) in rats. Journal of Chemistry and Pharmaceutical Research, 3, 2011: (3)322–327.
Odion EE, Abolagba JO, Igene JO, Usifoh SF, Omoti CE, Usifoh CO. Levels of Organochlorine in Cowpea from South-West Nigeria using Gas Chromatography-Mass Spectroscopy. South Asian Research Journal of Agriculture and Fisheries, 2, 2020 (3): 79-84
Kitada M, Ogura Y, Nitta K, Fujii M, Kanasaki K, Konishi K, Iida Y, Nakagawa A, Koya D, Effect of switching to teneligliptin from other dipeptidyl peptidase-4 inhibitors on glucose control and renoprotection in type 2 diabetes patients with diabetic kidney disease. Journal of Diabetes Investigation, 10, 2019, 706-713.
Comerford KB, Pasin G, Emerging evidence for the importance of dietary protein source on glucoregulatory markers and type 2 diabetes: Different effects of dairy, meat, fish, egg, and plant protein foods. Nutrients, 8, 2016, 446.
Alisi CS, Nwanyanwu CE, Akujobi CO, Ibegbulem CO, Inhibition of dehydrogenase activity in pathogenic bacteria isolates by aqueous extracts of Musa paradisiaca (Var Sapientum). African Journal of Biotechnology, 7, 2008 (12).
Uzairu SM, Kano MA, Assessment of phytochemical and mineral composition of unripe and ripe plantain (Musaparadisiaca) peels. African Journal of Food Science. 15, 2021: (3) 107-112.
Mahmood A., Ngah N, Omar MN. Phytochemicals Constituent and Antioxidant Activities in Musa x Paradisiaca Flower. European Journal of Scientific Research. 66. 2011, (2) 311-318.
Asquith TN, Butler LG, Interaction of condensed tannins with selected proteins. Phytochemistry. 25, 1986, 1591-1593.
Ojo OO, Nadro MS, Tella IO, Protection of rats by extracts of some common Nigerian trees against acetaminophen induced hepatoxicity. African Journal of Biotechnology. 5, 2006: (9)755-760.
Odion EE, Ogboru RO, Ighene MO, Identification of Compounds in Elaeis guineensis Fruits using GC-MS. Dhaka University Journal Pharmaceutical Science, 19, 2020: (2) 153-159.
Walczak KZ, Szczepankiewicz W, Module in chemistry, molecular sciences and chemical engineering. Elsevier Reference collection. 2020.
Egege AN, Nwaogwugwu JC, Nosiri CI, Okereke SC, GC-MS and Preliminary Phytochemical Constituents of CostusAfer Crude Stem Juice. Medicinal and Analytical Chemistry International Journal, 3, 2019: (4) 1-7.
Kamisah Y, Qodriyah HMS, Chua KH, Azlina MFN, Vitamin E: A potential therapy for gastric mucosal injury. Pharmaceutical Biology, 52, 2014: (12) 1591-1597.