Anticonvulsant activity of leaf extract of Heinsia crinata BIOLOGICAL ACTIVITY OF HEINSIA CRINATA

Barre latérale de l'article

PDF (English)
Publié-e : mars 31, 2021
Mots-clés :
HEINSIA CRINATA, ANTICONVULSANT, VEGETABLE

Contenu principal de l'article

Jude Okokon
Department of Pharmacology and Toxicology, University of Uyo
Koofreh Davies
DEPT OF PHARMACOLOGY AND TOXICOLOGY, UNIVERSITY OF UYO
Utibe A. Edem
DEPT OF PHARMACOLOGY AND TOXICOLOGY, UNIVERSITY OF UYO
Augustine I. Bassey
UNIVERSITY OF UYO, UYO, NIGERIA

Résumé

Background: Heinsia crinata(Afzel). G. Tayl. (Rubiaceae), is used in Ibibio ethnomedicine for the treatment of various diseases such as CNS disorders. The anticonvulsant activity of the leaf extract was studied.


Method: The ethanol leaf extract of H. crinata (450-1350 mg/kg) was investigated for anticonvulsant activity in mice against pentylenetetrazol, aminophylline and isoniazid-induced convulsion models to assess anticonvulsant activity.


Results: The extract was found to significantly (p<0.005-0.01) and dose-dependently offered protection against PTZ-, aminophylline and isoniazid-induced convulsions in mice.


Conclusion: The leaf extract of H. crinata possess anticonvulsant activity and this supports its use in ethnomedicine for the treatment of central nervous system disorders.

Téléchargements

Les données relatives au téléchargement ne sont pas encore disponibles.

Renseignements sur l'article

Comment citer
Okokon, . J., Davies, K. ., Edem, U. A. ., & Bassey, A. I. . (2021). Anticonvulsant activity of leaf extract of Heinsia crinata : BIOLOGICAL ACTIVITY OF HEINSIA CRINATA. Nigerian Journal of Pharmaceutical and Applied Science Research, 10(1), 20–25. Consulté à l’adresse https://nijophasr.net/index.php/nijophasr/article/view/414
Numéro
Vol. 10 No. 1 (2021): Nigerian Journal of Pharmaceutical and Applied Science Research (NIJOPHASR)
Rubrique
Articles
Licence Creative Commons

Cette œuvre est sous licence Creative Commons Attribution - Pas d'Utilisation Commerciale - Pas de Modification 4.0 International.

Références

Hutchinson J, Dalziel JM.. Flora of West tropical Africa. 2nd edition. Crown Agents for Overseas Government and Administration.Vol.1. part 2. 1954;p.638.

Babady-Billa, J., Chantal W., Suzane, T., Amuri, K., Georges, H. . Two triterpenoid saponins from Heinsia crinata.Phytochemistry. 1994; 36(6): 1489 – 1492

Ajibesin KK. Ekpo BA, Danladi B.. Comparative pharmacognostic and antimicrobial studies on leaves of two varieties of Heinsia crinata. Global Journal of Medical Sciences.2002; 2: 49-57.

Okokon JE, Umoh EE, Jackson CL, Etim E. I.. Antiplasmodial and antidiabetic activities of Heinsiacrinata. Journal of Medicinal Food. 2009;12(1): 231 - 236.

Ajibesin KK. Ekpo BA, DanladiB,Essien EE, Adesanya SA.. Ethnobotanical survey of Akwa Ibom State of Nigeria. J. Ethnopharm. 2008;115:387-408

Etuk EU, Bassey MN, Umoh U. O., Inyang, E.G. . Comparative microbial studies on three local varieties of Heinsia crinata. Plant varieties and seeds 1998;11: 151 – 158.

Etuk EU, Oforah EB, Uko NN.. Testicular and renal toxicity in rats administered extracts of Heinsia crinata leaves. Global Journal of Pure and Applied Sciences 2002;8: 253 – 257.

Andy IE, Eja ME, Mboto CI. An evaluation of the antimicrobial potency of Lasianthera africana (Beauv) and Heinsia crinata (G. Taylor) on Escherichia coli, Salmonella typhi, Staphylococcus aureus and Candida albicans.Malaysian J. Microbiol 2008;4(1): 25 – 29.

Ezeh C0, Ngene U, Onyekwelu K.. Antibiotic activity of Heinsia crinata. Indian Journal of Novel Drug Delivery.2014; 6(4): 351-354.

Okokon JE, Etebong EO, Umoh EE, Essien GA.. Antiulcerogenic activity of ethanolic leaf extract of Heinsia crinata. Journal of Pharmacy and Bioresources. 2010;7(2): 114-119.

Andrew UE, Okokon JE, Idiong OJ.. Antiinflammatory and analgesic activities of Heinsia crinata. Molecular and Clinical Pharmacol. 2012;3(1): 30-39.

Nwanna EE, Oboh G, Adedayo BC, Adewumi TM, Ejakpovi I.(. Biological effect of aqueous extract of Heinsiacrinata on lipid peroxidation and angiotensin-1- converting enzyme in vitro. Biosciences Research in Today’s World. 2015;1: 47-54.

Vellucci SV, Webster RA. Antagonism of caffeine-induced seizures in mice byRO15-1788. Eur J Ethnopharmacol.1984;97(3-4): 289-293.

Amabeoku GJ, Chikuni O.. Cimetidine – induced seizures in mice: antagonism by some gabaergic agents.BiochemPharmacol.1993;46: 2171 - 2175.

Juliet J, Subramanyam K, Suresh S.. Individual and combined effects of N6-cyclopentyladenosine, flunarizine and diazepam on aminophylline induced recurrent generalized seizures in mice. Polish J. Pharmacol. 2003;55:559 - 564.

Nanhakumar J, Tyagi MG.. Evaluation of cyclic nucleotide phosphodiesterase III inhibitors in animal models of epilepsy. Biomed Res 2008;19:13–17.

[Chu NS Caffeine and aminophylline-induced seizures: Epilepsia1981;22: 85 -95

Jensen MH, Jorgensen S, Nielsen H.. Is theophylline-induced seizure in man caused by inhibition of cerebral -nucleotidase activity. Acta Pharmacol. Toxicol.[1984];55: 331-334.

Sharma A, Sandhir R. Oxidative stress after lithium-pilocarpine induced status epilepticus in mice brain. Ann. Neurosci. 2006;13 :1 - 4.

Daval J, Nehlig A, Nicholas F.. Physiological & Pharmacological properties of adenosine : Therapeutic implications. Life Sci. 1991;49:1435 - 53.

Neering IR, Me Burney RM.. Role for microsomal calcium storage in mam-malian neurons? Nature (London) 1984;309:158 -160.

Tutka P, Turski WA, Kleinrok Z.. Influence of aminophylline and strychnine on the protective activity of excitatory amino acid antagonists against maximal electroshock-induced convulsions in mice. J Neural Transmission1996;103:307-314

Ray A, Gulati K, Anand S., Vijayan V. . Pharmacological studies on mechanisms of aminophylline –induced seizures in rats. Ind. J. Expl. Biol.2005;43: 849 -853.

De Sarro A, Cecchetti V, Fravlini V, Naccari F, Tabararrini O, De Sarro G. Effect of novel 6- desfluoroquinolones and classic quinolones on pentylene tetrazole induced seizures in mice. Antimicrob. Agents Chemother.1999;43:1729 – 1736.

Gale K.. GABA and epilepsy: Basic concepts from preclinical research.Epilepsia 1992;33:S3 – S12.

WestmorelandBF, Benarroch EE, Dube JR, ReganTJ, Sandok BA..Medical Neurosciences.Mayo Foundation ,Rochester.1991;pp.307 – 312.

Porter RJ, Meldrum BS.. Antiseizure drugs. In: Katzung BG. (Ed), Basic and Clinical Pharmacology. 8th ed. Lange Medical Books/McGraw-hill, New York. 2001;pp.403 – 417.

Rang HP, Dale MM, Ritter JM, Moore P K..Pharmacology, 5th ed.Churchill Livingstone. Edinburg.2003; pp.557 - 587.

Amabeoku GJ, Green I, Kabatende J.(. Anticonvulsant activity of Cotyledon orbiculata L. (Crassulaceae) leaf extract in mice. J Ethnopharmacol,2007;112: 101-107.

Corda MG, Costa E, Guidotti A.. Specific proconvulsant action of an imidazobenzodiazepine (Ro 15-1788) on isoniazid convulsions. Neuropharmacology, 1982;21(1): 91-4.

Uzman S, Yanaral TU, Topta? M, Koç A, Ta? A, Bican G.. Acute isoniazid intoxication: An uncommon cause of convulsion, coma and acidosis. TüberkülozveToraks, 2013;61(1): 50-53.

Bassin S, Smith TL, Bleck TP.. Clinical review: Sta¬tus epilepticus. Critical Care.2002) 6(2): 137-42.

Brophy GM, Bell R, Claassen J, Alldredge B, Bleck TP, Glauser T. . Guidelines for the evaluation and man¬agement of status epilepticus. Neurocritical care 2012;17(1): 3-23

Meierkord H, Boon P, Engelsen B. EFNS guideline on the management of status epilepticus in adults. Eur J Neurology, 2010;17(30): 348-55.

Tajender V, Saluja J. INH induced status epilepticus: Re¬sponse to pyridoxine. Indian Journal of Chest Diseases and Allied Sciences, 2006;48(3), 205-206.

Romero JA, Kuczler FJ.. Isoniazid overdose. Rec¬ognition and Management. American Family Physician,1998;57(4): 749-752.