Qualitative Phytochemical Screening and In-vitro Antimicrobial studies of extracts of Dyschoriste pedicellata (Acanthaceae)

Contenu principal de l'article

G.Y. Kantiok
M.S. Sallau
O.R.A. Iyun

Résumé

The plant Dyschoriste pedicellata (Acanthaceae) was investigated for its medicinal potential. The method of cold maceration was employed for extraction using petroleum ether, ethyl acetate and methanol sequentially. The preliminary phytochemical screening revealed the presence of alkaloids, tannins, flavonoids, saponnins, glycosides and steroids. The crude extracts were evaluated for antimicrobial potential using the following clinical isolates; Staphylococcus aureus, Salmonella typhi, Streptococcus pyogenes, Escherichia coli, Streptococcus pneumonia, Klebsiella pneumonia, Candida albicans, and Aspergillus niger. The zone of inhibition of test organisms ranged from 10 – 17 mm (pet ether), 13 – 23 mm (ethyl acetate), and 12 - 28 mm (methanol). These were compared with Ampiclox (26 mm), ciprofloxacin 20 – 24 mm, Amoxicillin 15 mm and Fluconazole (20 mm). The Minimum Inhibitory Concentration (MIC) showed that pet ether extract had an MIC of 12.5 mg/ml against Streptococcus pneumonia and Klebsiella pneumonia. The methanol and ethyl acetate fractions had MIC values of 6.25 mg/ml against Aspergillus niger. The presence of phytochemicals such as alkaloids, tannins, flavonoids, saponnins and glycosides and also the observed antimicrobial activity of the extracts are potentials present in Dyschoriste pedicellata worth investigating.

Téléchargements

Les données relatives au téléchargement ne sont pas encore disponibles.

Renseignements sur l'article

Comment citer
Kantiok, G. ., Sallau, M. ., & Iyun, O. . (2020). Qualitative Phytochemical Screening and In-vitro Antimicrobial studies of extracts of Dyschoriste pedicellata (Acanthaceae). Nigerian Journal of Pharmaceutical and Applied Science Research, 9(3), 35–39. Consulté à l’adresse https://nijophasr.net/index.php/nijophasr/article/view/359
Rubrique
Articles
Bibliographies de l'auteur-e

G.Y. Kantiok

Department of Chemistry, Ahmadu Bello University, Zaria

M.S. Sallau

Department of Chemistry, Ahmadu Bello University, Zaria

O.R.A. Iyun

Department of Chemistry, Ahmadu Bello University, Zaria

Références

Aba, O. Y., Ezuruike, I.T., Ayo, R.G., Habila, J. D. and Ndukwe, G. I. (2015). Isolation, antibacterial and antifungal evaluation of ?-amyrenol from the root extract of Acacia ataxacantha DC. Sch. Acad. J. Pharm. 4(2): 124-131

Abdullahi, A., Musa, M.I., Haruna, A. M., Sule, A. K., Iliya, I. (2011) Antimicrobial Flavonoid Diglycosides from the leaves of Ochna scheinfurthiana (Ochnaceae). Nig. Journal of Pharmaceutical Sciences.10(2);1-7

Amin, N., Al-masri, M., Naser, A., Hussein, F., Al-rimawi, F., Abu, A., … Ghonaim, S. (2017). European Journal of Integrative Medicine Phytochemical , antimicrobial and antioxidant preliminary screening of a traditional Palestinian medicinal plant , Ononis pubescens L . European Journal of Integrative Medicine, 14(May), 46–51. https://doi.org/10.1016/j.eujim.2017.08.012

Akerele, J. O.; Ayinde, B. A. and Ngiagh, J. (2011) Comparative Phytochemical and Antimicrobial activities of the leaf and root bark of Newbouldia leaves seem (Bignoniaceae) on some clinically isolated bacterial organisms. Nig Journal of Pharmaceutical Sciences 10(2); 8-13

Awan, J.A., Ahmed, B.C., Uzair, M., Aslam, S. M., Ishfaq, K. (2014). Family acanthaceae and genus aphelandra: ethnopharmacological and phytochemical review. International Journal of Pharmacy and Pharmaceutical Sciences, 6(10): 44-55

Barbieri, R., Coppo, E., Marchese, A., Daglia, M., Sobarzo-Sanchez, E., Nabavi, M. (2016). Phytochemicals for human disease: An update on plant-derived compounds antibacterial activity. Microbiological Research http://dx.doi.org/doi:10.1016/j.micres.2016.12.003

Burkill, H.M., (1985). Entry for Dyschoriste pedicellata C.B.Clarke [family ACANTHACEAE].In: The useful plants of west tropical Africa, Vol 1. Royal Botanical Gardens, Kew, UK

Ewansiha J. U., Garba S. A., Mawak J. D., Oyewole O. A (2012). Antimicrobial Activity of Cymbopogon Citratus (Lemon Grass) and Its Phytochemical Properties. Frontiers in Science 2(6): 214-220 DOI: 10.5923/j.fs.20120206.14

G. Trease, W. Evans, Pharmacognosy, 12th ed., Bailliere Tindall, London, (1983).

Guo Zongru. (2017). The modification of natural products for medicinal use. Acta Pharmaceutica Sinica B 7(2), 119-136

Iqbal, E., Salim, K.A., Lim, B.L. (2015). Phytochemical screening, total phenolics and antioxidant activities of bark and leaf extracts of Goniothalamus velutinus (Airy Shaw) from Brunei Darussalam. Journal of King Saud University – Science (27) 224–232. http://dx.doi.org/10.1016/j.jksus.2015.02.003

Jaradat, N.A., Al-Masri, M., Zaid, A.N., Hussein, F., Al-Rimawi, F., Mokh, A.A., …Ghonaim, S. (2017). Phytochemical, antimicrobial and antioxidant preliminary screening of a traditional palestinian medicinal plant, Ononis pubescens L. European Journal of Integrative Medicine 14, 46-51.

Sofowora, A. (1993).Medicinal plants and traditional medicine in Africa. 2nd Edition, John Wiley and sons Ltd, United kingdom.

Odoh, U. E., Ezugwu, C. O. and Ezejiofor, M. (2011). Pharmacognostic Studies on the Leaves of Dyschoriste Perottetii Nees. Pharmacognosy Journal. 3(4) DOI: 10.5530/pj.2011.24.3

Vellokobia, A.; Kostalova, D and Sochorova, K. (2001). Isoquinoline alkaloid from Mahonia aquifolium stem bark active against Neisseria species. Folia Microbiol. 46:107-111 Springer Science& Business Media, Germany, 1998.

Yakubu, M. B., Lawal, A.O. & Jasper, E. E. (2018). GC-MS Analysis of Ethyl Acetate Fraction of the whole Plant Extract of Dyschoriste perrottetii (Acanthaceae). Nigerian Journal of Chemical Research;23(1), 52-58