Determination of Aspirin Stability in oil in Water Emulsion prepared using different oils and Gums.

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Publié-e : sept. 1, 2020
Mots-clés :
Aspirin, Emulsion, Oils, Okra mucilage

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Afokoghene Avbunudiogba John
Ikhuoria Arhewoh Matthew
Okiemute Imonije Juliet

Résumé

The poor stability of aspirin in aqueous medium is a major drawback in the formulation of aspirin in liquid dosage form. This study is aimed at formulating stable oil preparation of aspirin with okra (Abelmoschus esculentus L) mucilage as emulsifying agent. The emulsion was formulated by dispersing the aspirin in the oily phase which was then dispersed in the aqueous continuous phase. The specific density, pH, organoleptic properties and aspirin content of the emulsions were evaluated. The effect of the okra mucilage was compared to acacia which serve as a standard natural emulsifying agent. Emulsions of acacia gave pH of 3.18, 3.31, and 3.35 compared to those of okra mucilage (O.M) with pH of 3.11, 3.10 and 3.06. The percentage content and stability were better in olive oil emulsion compared to emulsions made of palm oil and shea butter. The organoleptic properties of the formulations varied with the viscosity of the oils. This study showed that aspirin and okra mucilage have good compatibility with olive oil, which can serve as a means of formulating aspirin emulsion to enhance compliance in children. O.M can be useful in formulating stable emulsions when combine with other natural emulsifiers in small quantities.

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John , A. A., Matthew , I. A., & Juliet , O. I. (2020). Determination of Aspirin Stability in oil in Water Emulsion prepared using different oils and Gums. Nigerian Journal of Pharmaceutical and Applied Science Research, 9(3), 40–45. Consulté à l’adresse https://nijophasr.net/index.php/nijophasr/article/view/358
Numéro
Vol. 9 No. 3 (2020)
Rubrique
Articles
Licence Creative Commons

Cette œuvre est sous licence Creative Commons Attribution - Pas d'Utilisation Commerciale - Pas de Modification 4.0 International.

Bibliographies de l'auteur-e

Afokoghene Avbunudiogba John

Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmacy, Delta State University, Abraka

Ikhuoria Arhewoh Matthew

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City.

Okiemute Imonije Juliet

Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmacy, Delta State University, Abraka

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