Quality Assessment of Various Brands of Ciprofloxacin Hydrochloride Tablets Sold In Uyo Metropolis

Contenu principal de l'article

Arnold C. Igboasoiyi
Amarachi C. Offor
Amarachi P. Egeolu

Résumé

Ciprofloxacin is a flouroquinoline antibiotic with a broad spectrum of activity used for the treatment of various bacterial infections including anthrax. The use of substandard or fake ciprofloxacin products will jeopardise their usefulness. Hence, the need for provisions of simple and cost-effective method(s) of assay that will encourage regular and quick sampling of ciprofloxacin tablets. Different brands of ciprofloxacin hydrochloride tablets purchased randomly from drug stores in the study centre, and coded A-J, were assayed for weight uniformity, friability, hardness, disintegration, dissolution rate using standard physical methods. Their percentage drug contents were determined using spectrophotometric and titrimetric methods. The spectrophotometric measurement was done at a wavelength of 276nm while the titrimetric method was based on oxidative reaction between ciprofloxacin and potassium permanganate yielding the oxide as a greyish pink colour at end point. All the brands met the requirements for weight uniformity, friability, disintegration and dissolution. Only one brand, sample E, failed the hardness test. The titrimetric and spectrophotometric assay showed that seven of the brands met the British Pharmacopoeia requirement for percentage drug content (95.0-105.0%). Statistical analysis showed no significant difference (p<0.05) between the results obtained from both the titrimetric and spectrophotometric methods. The two methods are reliable, simple and cost-effective and can be routinely used to assay ciprofloxacin tablets.

Téléchargements

Les données relatives au téléchargement ne sont pas encore disponibles.

Renseignements sur l'article

Comment citer
Igboasoiyi, A. C. ., Offor, A. C. ., & Egeolu, A. P. . (2020). Quality Assessment of Various Brands of Ciprofloxacin Hydrochloride Tablets Sold In Uyo Metropolis. Nigerian Journal of Pharmaceutical and Applied Science Research, 7(2), 89–93. Consulté à l’adresse https://nijophasr.net/index.php/nijophasr/article/view/225
Rubrique
Articles
Bibliographies de l'auteur-e

Arnold C. Igboasoiyi

Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Uyo, Uyo, Akwa Ibom State, Nigeria.

Amarachi C. Offor

Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Uyo, Uyo, Akwa Ibom State, Nigeria

Amarachi P. Egeolu

Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Uyo, Uyo, Akwa Ibom State, Nigeria.

Références

Adegbolagun, O. A., Olalade, O. A. and Osumah, S. E. (2007). Comparative Evaluation of the Biopharmaceutical and Chemical Equivalence of some Commercially Available Brands of Ciprofloxacin Hydrochloride Tablets. Tropical Journal of Pharmaceutical Research, 6 (3): 737-745.

American Academy of Pediatrics. (2015) Red Book: 2015 Report of the Committee on Infectious Diseases. 30th ed. Elk Grove Village, IL: American Academy of Pediatrics.

American Medical Association (2001). Diagnosis and management of foodborne illnesses: a primer for physicians. MMWR Recomm Rep. 50(RR-2):1-69.

Andersson, M. I. and MacGowan, A. P. (2003). Development of the Quinolones. Journal of Antimicrobial Chemotherapy, 51 (1): 1-11.

Bearden, D. T. and Danziger, L. H. (2001). Mechanism of Action of and Resistance to Quinolones. Pharmacotherapy, 21 (10): 224-232.

British Pharmacopoeia (2008). Monographs on Medicinal and Pharmaceutical Substances. Her Majesty’s Stationery Office, London. 1: 534-537.

British Pharmacopoeia (2015). British Pharmacopoeia Commission, London. 3: 320.

Dixon TC, Meselson M, Guillemin J, Hanna PC. (1999). Anthrax. The New England Journal of Medicine 341:815-826. [PubMed 10477781]

Drugs.com (2018). Ciprofloxacin Monograph for Professionals. https://www.drugs.com/monograph/ciprofloxacin.html. Retrieved 28/04/18

Duggirala, A., Joseph, J., Sharma, S., Nutheti, R., Garg, P., Das, T. (2007). Activity of Newer Fluoroquinolones Against Gram-Positive and Gram-Negative Bacteria Isolated from Ocular Infections: An In Vitro Comparison. Indian Journal of Opthalmology, 55 (1): 15-19.

Getu, K and Awot, G.E (2010). Quality Assessment of the Commonly Prescribed Antimicrobial Drug, Ciprofloxacin Tablets, Marketed in Tigray, Ethiopia. MEJS Volume 2 (1): 93-107. DOI.10.4314/mejs.v2i1.49656

Ghelani R (2017). Ciprofloxacin Patient Information uses, dosage, warnings, side effects.

http://www.netdoctor.co.uk/medicines/infections/a28009/ciprofloxacin-uses-and- things-to-know/ Retrieved 24/04/2018

Igboasoiyi A.C., Attih E.E., Ofoefule S.I., Umoh E.D. and Udoh O.C. (2014). Spectrophotometric Determination of Ciprofalxocin Using Charge-Transfer Complexation Technique. International Journal of Innovative Research and Development. 3(11): 177-182

Jaman M., Chowdhury A. A. , Rana1 A. A., Masum S. M., Ferdous T., Rashid M. A. and Karim. M. M. (2015). In vitro evaluation of Ciprofloxacin Hydrochloride. Bangladesh J. Sci. Ind. Res. 50(4), 251-256.

Jantratid, E., Janssen, N., Reppas, C. and Dressman, J. B. (2008). Dissolution Media Simulation Conditions in the Proximal Human Gastrointestinal Tract: An Update. Pharmaceutical Resources, 25: 1663-1676.

Olaniyi A.O. and Ogungbamila F.O. (1998). Experimental Pharmaceutical Chemistry 2nd Reprint, Shaneson C.I. Limited, Ibadan

Shah V. P. (2001), Dissolution: a quality control test vs a bioequivalent test. Dissolution Technologies 8(4): 1–2.

Stamm, W E. and Norrby, S. R. (2001). Urinary Tract Infections: Disease Panorama and Challenges. The Journal of Infectious Diseases, 183 (1): S1-S4.

Uivarosi, V. (2013). Metal Complexes of Quinolone Antibiotics and their Applications. An Update. Molecules, 18 (9): 11153-11197.

United States Pharmacopoeia (USP). 24 NF 19. United States Pharmacopoeia Convention Incorporation , pp 1882-1883

United States Pharmacopoeia National Formulary USP 37NF 32. (2014). Ciprofloxacin Official Monograph, United States Pharmacopeial Convention 12601. Twinbrook, Parkway, Rockville MD 20852, 2:2355-2356

World Health Organization (2015). 19th WHO Model List of Essential Medicines, p. 8.

Articles similaires

Vous pouvez également Lancer une recherche avancée d’articles similaires à cet article.