Effect of Peristrophe bicalyculata Leaf Extract on Oxidative Stress Enzymes and Haematological Indices of Pentylenetetrazole-induced Kindled Rats
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Peristrophe bicalyculata extract is used in the management of convulsions and snake bites among other uses in northern Nigeria. In the present study, the effect of methanol leaf extract of P. bicalyculata (200 and 400 mg/kg) was evaluated on the course of kindling, oxidative stress markers and haematologic indices using pentylenetetrazole (PTZ)-induced kindled rats. Preliminary phytochemical screening of the extract was also carried out. Phytochemical screening showed the presence of alkaloids, glycosides, cardiac glycosides, saponins, steroids, triterpenes, tannins and flavonoids. P. bicalyculata extract at all doses tested reduced the severity of seizure episodes induced by PTZ. Evaluation of oxidative stress biomarkers showed no significant differences (p>0.05) in the levels of malondialdehyde, however, the glutathione levels were significantly (p<0.01) increased at 200 and 400 mg/kg of the extract treated groups. Haematological findings revealed a significant (p<0.01) increase in lymphocyte levels at 200 mg/kg of the extract as well as the standard drug (valproic acid) used. The results revealed that, the methanol leaf extract of Peristrophe bicalyculata possesses anticonvulsant activity in chronic seizure model and thus, posseses antiepileptogenic properties with no antioxidant activity.
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Abdulazeez AM, Awasum CA, Dogo YS, Abiayi PN. (2011). Effect of Peristrophe bicalyculata on the blood pressure and kidney and liver functions of two kidney-1-clip hypertensive rats. Br J Pharmacol Toxicol; 1(2): 101-107.
Abimbola AM, Baba IA, Yenusa EZ, Omanibe SJ, Oladimeji IH (2013). Anti-trypanosomal effect of Peristrophe bicalyculata extract on Trypanosoma brucei brucei-infected rats. Asian Pac J Trop Biomed. 3(7): 523-531.
Acharya S, Bussel JB (2000). Hematologic toxicity of sodium valproate. J Pediatr Hematol Oncol. 22(1): 62-65.
Bachmann T, Bertheussen KH, Svalheim S, Rauchenzauner M, Luef G, Gjerstad L, Tauboll E. (2011). Haematological side effects of antiepileptic drug treatment in patients with epilepsy. Acta Neurol Scand Suppl. 191: 23-27.
Bashkatova V, Narkevich V, Vitskova G, Vanin A (2003). The influence of anticonvulsant and antioxidant drugs on nitric oxide level and lipid peroxidation in the rat brain during pentylenetetrazole-induced epileptiform model seizures. Progress Neuropsychopharmacol Biol Psychiatry. 27(3): 487-492.
Becker A, Grecksch G, Ruthrich HL, Pohle W, Marx B, Matthies H (1992). Kindling and its consequences on learning in rats. Behav Neural Biol. 57: 37-43.
Becker A, Tiedge A, Grecksch G (1997). Diazepam-its effects on the development of pentylenetetrazol kindling, related learning impairments, and neuronal cell loss. Pharmacol Res. 35: 27-32.
Burkill, H.M. (1985). The useful plant of West Tropical Africa. Vol. 1, Royal Botanic Gardens, Kew.
Choudhary K, Mishra MA, Poroikov VV, Goel RK (2013). Ameliorative effect of Curcumin on seizure severity, depression like behavior, learning and memory deficit in post-pentylenetetrazole-kindled mice. Eur J Pharmacol, 704: 33-40.
Dal-Pizzol F, Klamt F, Vianna MM, Schro¨der N, Quevedo J, Benfato MS (2000). Lipid peroxidation in hippocampus early and late after status epilepticus induced by pilocarpine or kainic acid in wistar rats. Neurosci Letters. 291(3):179-182.
Dhir A, Naidu PS, Kulkarni SK (2007). Neuroprotective effect of nimesulide, a preferential COX-2 inhibitor against pentylenetetrazole (PTZ)-induced chemical kindling and associated biochemical parameters in mice. Seizure. 16: 691-697.
Dorszewska J, Winczewska-Wiktor A, Sniezawska A, Kaczmarek I, Steinborn B (2009). Homocysteine and asymmetric dimethylarginine (ADMA) in epilepsy. Przegl Lek, 66: 448-452.
Estevez AY, Pritchard S, Harper K, Aston JW, Lynch A, Lucky JJ, Ludington JS, Chatani P, Mosenthal WP, Leiter JC, Andreescu S, Erlichman JS (2011). Neuroprotective mechanisms of cerium oxide nanoparticles in a mouse hippocampal brain slice model of ischemia. Free Radic Biol Med. 51: 1155-1163.
Evans WC (2002). Trease and Evans Pharmacognosy, (Fifteenth Edition) Saunders Company Limited, London. pp. 191-193.
Faggion SA, Cunha AS, Fachim HA, Gavin AS, dos Santos WF, Pereira AM, Beleboni RO (2011). Anticonvulsant profile of the alkaloids (+)-erythravine and (+)-11-?-hydroxyerythravine isolated from the flowers of Erythrina mulungu Mart ex Benth (Leguminosae-Papilionaceae). Epilepsy Behav. 20(3): 441-446.
Fiest KM, Birbeck GL, Jacoby A, Jette N (2014). Stigma in epilepsy. Curr Neurol Neurosci Rep 14(444): 1-6.
Gooch CL, Pracht E, Borenstein AR (2017). The burden of neurological disease in the United States: a summary report and call to action. Ann Neurol. 81: 479-484.
Gupta YK, Shirma M, Chaudhary G (2001). Antiepileptic activity of Panax ginseng against pentylenetetrazole-induced kindling in rats. Indian J Pharmacol. 45(4): 502-506.
Halliwell B (1996). Free radicals, proteins and DNA: oxidative damage versus redox regulation. Biochem Soc Transact, 24(4): 1023-1027.
Handoko KB, Souverein PC, Van Staa TP, Meyboom RH, Leufkens HG, Egberts TC (2006). Risk of aplastic anemia in patients using antiepileptic drugs. Epilepsia, 47: 1232-1236.
Qi ST, Huang LJ, Wang KW, Kong WD, Peng L, Huang SP, Feng WF, Zhang XA (2001). Association of epileptiform activity with neuronal death in the CA3 subfield of the hippocampus following focally evoked limbic seizures. Di Yi Jun Yi Da Xue Xue Bao; 21(11): 831-833.
Janakiraman N, Sahaya SS, Johnson M (2012). Anti-bacterial studies on Peristrophe bicalyculata (Retz.) Nees. Asian Pac J Trop Biomed 2(1): 147-150.
Kong Q, Lin, CG (2010). Oxidative damage to RNA: mechanisms, consequences, and diseases. Cell Mol Life Sci. 67(11): 1817-1829.
Kurhaluk N, Sliuta A, Kyriienko S, Winklewski PJ (2017). Melatonin restores white blood cell count, diminishes glycated haemoglobin level and prevents liver, kidney and muscle oxidative stress in mice exposed to acute ethanol intoxication. Alcohol Alcohol. 52(5): 521-528.
Linnebank M, Moskau S, Semmler A, Widman G, Stoffel-Wagner B, Weller M, Elger CE (2011). Antiepileptic drugs interact with folate and vitamin B12 serum levels. Ann Neurol. 69: 352-359.
Malinska D, Kulawiak B, Kudin AP, Kovacs R, Huchzermeyer C, Kann O, Szewczyk A, Kunz WS (2010). Complex III-dependent superoxide production of brain mitochondria contributes to seizure-related ROS formation, Biochimica Biophysica Acta, 1797 (6-7): 1163-1170.
Mason CR Cooper RM (1972). A permanent change in convulsive threshold in normal and brain damaged rats with repeated small doses of pentylenetetrazole. Epilepsia 1972; 13: 663-674.
Ono J, Vieth RF, Walson PD (1990). Electrocorticographical observation of seizures induced by pentylenetetrazol (PTZ) injection in rats. Functional Neurol. 5: 345-352.
Ozdemir, O, Yakut A, Dinleyici EC, Aydogdu SD, Yarar C, Colak O (2011). Serum asymmetric dimethylarginine (ADMA), homocysteine, vitamin B (12), folate levels, and lipid profiles in epileptic children treated with valproic acid. Eur J Pediatr, 170: 873-877.
Patsoukis N, Zervoudakis G, Georgiou CD, Angelatou F, Matsokis NA, Panagopoulos NT (2004). Effect of pentylenetetrazole-induced epileptic seizure on thiol redox state in the mouse cerebral cortex. Epilepsy Res. 62(1): 65-74.
Rang HP, Ritter JM, Flower RJ, Hendrson G (2016). Rang and Dales Pharmacology; 8thedition. Churchill Livingstone, Elsevier science limited, pp. 546-558.
Rashmi G, Jaya P, Hardik P, Bhumi M, Shivani A (2010). Peristrophe bicalyculata - A Review. Pharmacog J, 2(14): 39-45.
Rauca, C., Zerbe, R. and Jantze, H. (1999). Formation of free hydroxyl radicals after pentylenetetrazole-induced seizure and kindling. Brain Res. 847: 347-851.
Rossi J (1996). Sensitization induced by kindling and kindling related phenomena as a model for multiple chemical sensitivity. Toxicol. 111: 87–100.
Schulz JB, Linderau J, Dichgans J (2000). Glutathione, oxidative stress and neurodegeneration. Eur J Biochem. 276(16): 4904-4911.
Sejima H, Ito M, Kishi K, Tsuda H, Shiraishi H (1997). Regional excitatory and inhibitory amino acid concentrations in pentylenetetrazole kindling and kindled rat brain. Brain Dev. 19: 171-175.
Stamler JS, Simon DJ, Jaraki O (1992). S-nitrosylation of tissue-type plasminogen activator confers vasodilatory and antiplatelet properties on the enzyme,” Proceedings of the National Academy of Sciences of the United States of America, 89(17): 8087-8091.
Takemiya T, Suzuki K, Sugiura H, Yasuda S, Yamagata K, Kawakami Y, Maru E (2003). Inducible brain COX-2 facilitates the recurrence of hippocampal seizures in mouse rapid kindling. Prostaglandins Lipid Mediators. 71: 205-216.
Tan DX, Manchester LC, Reiter RJ, Qi W, Kim SJ, El-Sokkary GH (1998). Melatonin protects hippocampal neurons in vivo against kainic acid-induced damage in mice. J Neurosci Res. 54(3): 382-389.
Tanavade SS, Naikwade NS, Chougule DD (2012). In vitro anticancer activity of ethanolic extracts of Peristrophe bicaliculata Nees. Int J Chem Sci, 10(1): 317-323.
Willmore LJ, Triggs WJ, Gray JD (1986). The role of iron-induced hippocampal peroxidationin acute epileptogenesis. Brain Res. 382(2): 422-426.
Winyard PG, Mody CJ, Hacob C (2005). Oxidative Activation of Antioxidant Defense. Trends Biochem Sci. 30: 453-461.
Yuksel A, Cengiz M, Seven M, Ulutin T (2000). Erythrocyte glutathione, glutathione peroxidase, superoxide dismutase and serum lipid peroxidation in epileptic children with valproate and carbamzepine monotherapy. J Basic Clin Pharmacol. 11(1): 73-81