Review of Pharmacognostic Features, Phytochemical Constituents and Pharmacological Actions of Melastoma malabathricum LINN (Melastomaceae)
Barre latérale de l'article
Contenu principal de l'article
Résumé
Melastoma malabathricum is a medicinal plant found in tropical and temperate Southeast Asian countries. It has been used for a long period in traditional medicine. Moreover, various scientific investigations reported have shown that that the plant is effective against various diseases due its phytochemical constituents. This study aimed to review the studies carried on Melastoma malabathricum in order to have comprehensive information on its phytochemical constituents and pharmacological action (therapeutic uses). The data were searched from electronic data bases and some printed materials. The key word used for searching information is Melastoma malabathricum. The electronic sources of data include; highwire, googlescholar, sciencedirect and pub med. The review revealed that Melastoma malabathricum has potent therapeutic activities such as antidiabetic, antihyperlipidemic, antibacterial, antifungal, antiparasitic, antiviral, antiulcer and antidiarrheal activity. It was also reported to have antioxidant as well as hepatoprotective activity. Melastoma malabathricum contains different classes of secondary metabolites such as triterpenoid, alkaloids, amide, flavonoids anthocyanins, hydrolysable tannins and steroidal tannins. Other phytochemical constituents such as alpha –amyrin, patriscabratine, auranamide, quercetin, quercitrin, kaempferol-3-O-( 2” , 6” -di-O-p-trans-coumaroyl)-beta-glucoside, rutin, malabathrin B, C, and D. 1,2,4,6- tetra-O-galloyl-?-D-glucoside, pterocarinin C, pasuarictin, pedunculagin, 1,4,6-tri-O-galloyl-?-D-glucoside, strictinin, nobotanins B, G, H and J were isolated from M. malabathricum
Téléchargements
Renseignements sur l'article
Cette œuvre est sous licence Creative Commons Attribution - Pas d'Utilisation Commerciale - Pas de Modification 4.0 International.
Références
Ado, M. A., Abas, F., Mohammed, A. S., & Ghazali, H. M. (2013). Anti- and pro-lipase activity of selected medicinal, herbal and aquatic plants, and structure elucidation of an anti-lipase compound. Molecules, 18(12), 14651–14669.
Aishah, B., Nursabrina, M., Noriham, A., Norizzah, A. R., & Mohamad S. H. (2013). Anthocyanins from Hibiscus sabdariffa, Melastoma malabathricum and Ipomoea batatas and its color properties. International Food Research Journal, 20(2), 827–834.
Alnajar, Z. A. A., Abdulla, M. A., Ali, H. M., Alshawsh, M. A., & Hadi, A. H. A. (2012). Acute toxicity evaluation, antibacterial, antioxidant and immunomodulatory effects of Melastoma malabathricum. Molecules, 17(3), 3547–3559.
Alwash, M. S. A., Ibrahim, N., Yaacob, W. A., & Din, L. B. (2014). Antibacterial, antioxidant and cytotoxicity properties of traditionally used Melastoma malabathricum linn leaves. Advance Journal of Food Science and Technology, 6(1), 6–12.
Alwash, M. S., Ibrahim, N., & Ahmad, W. Y. (2013a). Bio-guided study on Melastoma malabathricum Linn leaves and elucidation of its biological activities. American Journal of Applied Sciences, 10(8), 767–778.
Alwash, M. S., Ibrahim, N., & Ahmad, W. Y. (2013b). Identification and mode of action of antibacterial components from Melastoma malabathricum Linn leaves. American Journal of Infectious Diseases, 9(2), 46–58.
Anuar, N., Mohd Adnan, A. F., Saat, N., Aziz, N., & Mat Taha, R. (2013). Optimization of extraction parameters by using response surface methodology, purification, and identification of anthocyanin pigments in melastoma malabathricum fruit. The Scientific World Journal.
Balamurugan, K., Nishanthini, A., & Mohan, V. R. (2013a). Antidiabetic and antihyperlipidaemic activity of ethanol extract of Melastoma Malabathricum L . leaf in alloxan induced diabetic rats. International Journal of Pharmaceutical Research and Bio-Science, 2(5), 223–236.
Balamurugan, K., Nishanthini, A., & Mohan, V. R. (2013b). Anti-diarrheal activity of Melastoma malabathricum L . leaf extracts (Melastomataceae). International Journal of Herbal Medicine, 1(2), 102–105.
Balamurugan, K., Nishanthini, A., & Mohan, V. R. (2013c). Antiulcer activity of Melastoma malabathricum L. leaf extracts (Melastomataceae). International Journal of Advanced Research, 1(5), 49-52.
Balamurugan, K., Nishanthini, A., & Ramasamy, M. (2014). Antidiabetic and antihyperlipidaemic activity of ethanol extract of Melastoma malabathricum Linn. leaf in alloxan induced diabetic rats. Asian Pacific journal of tropical Biomedicine, 4(1), S442–S448.
Balamurugan, K., Sakthidevi, G., & Mohan, V. R. (2012). Anti-inflammatory activity of leaf of Melastoma malabathricum L. (Melastomataceae). International Journal of Research in Ayurveda and Pharmacy, 3(6), 801–802.
Balamurugan, K., Sakthidevi, G., & Mohan, V. R. (2013d). Stimulatory effect of the ethanol extract of Melastoma malabathricum L. (Melastomataceae) leaf on the reproductive system of male albino rats. Journal of Applied Pharmaceutical Science, 3(02), 160–165.
Basripuzi, H. B., Sani, R. A., Ariff, O. M., & Chandrawathani, P. (2013). Evaluation of enhanced virgin coconut oil and senduduk (Melastoma malabathricum) as anthelmintics against caprine strongyle nematodes. Tropical Biomedicine, 30(3), 516–525.
Begum, D., & Nath, S. C. (2000). Ethnobotanical review of medicinal plants used for skin diseases and related problems in Northeastern India. Journal of Herbs, Spices and Medicinal Plants, 7(3), 55–93.
Burkill, I. (1966). A dictionary of the economic products of the Malay Peninsula. A Dictionary of the Economic Products of the Malay Peninsula. 2(2nd edition).
Cavin A., Dyatmyko W., & Hostettmann, K. (1999). Screening of Indoesian plants for antifungal and free radical scavenging activities. Pharmaceutical Biology, 37(4), 260–268.
Che Omar, S. N., Ong Abdullah, J., Khairoji, K. A., Chin Chin, S., & Hamid, M. (2013). Effects of flower and fruit extracts of Melastoma malabathricum Linn. on growth of pathogenic bacteria: Listeria monocytogenes, Staphylococcus aureus, Escherichia coli, and Salmonella typhimurium. Evidence-Based Complementary and Alternative Medicine, 2013.
Choudhury, M. D., Nath, D., & Talukdar, A. D. (2011). Antimicrobial Activity of Melastoma malabathricum L . Assam University Journal of Science and Technology, 7(1), 76–78.
Chuah, E. L., Zakaria, Z. A, Suhaili, Z., Bakar, S. A., & Desa, M. N. M. (2014). Antimicrobial activities of plant extracts against methicillin-susceptible and methicillin-resistant Staphylococcus aureus. Journal of Microbiology Research, 4(1), 6–13.
Diris, M. N., Basri, A. M., Metali, F., Ahmad, N., & Taha, H. (2017). Research Article Phytochemicals and Antimicrobial Activities of Melastoma malabathricum and Melastoma beccarianum Leaf Crude Extracts. Halim, S. Z., Zakaria, Z. A., Omar, M. H., Mohtarrudin, N.,
Wahab, I. R. A., & Abdullah, M. N. H. (2017). Synergistic gastroprotective activity of methanolic extract of a mixture of Melastoma malabathricum and Muntingia calabura leaves in rats. BMC complementary and alternative medicine, 17(1), 488.
Hussain, F., Abdulla, M. A., Noor, S. M., Ismail, S., & Ali, H. M. (2008). Gastroprotective effects of Melastoma malabathricum aqueous leaf extract against ethanol-induced gastric ulcer iin rats. American Journal of Biochemistry and Biotechnology, 4(4), 438–441.
Jaios, E. S., Rahman, S. A., Ching, S. M., Kadir, A. A., Desa, M., Mohd, N., & Zakaria, Z. A. (2016). Possible mechanisms of antinociception of methanol extract of Melastoma malabathricum leaves. Revista Brasileira de Farmacognosia, 26(5), 586-594.
Joffry, S. M., Yob, N. J., Rofiee, M. S., Affandi, M. R. M., Suhaili, Z., Othman, F., & Zakaria, Z. A. (2012). Melastoma malabathricum (L.) smith ethnomedicinal uses, chemical constituents, and pharmacological properties: A review. Evidence-Based Complementary and Alternative Medicine, 2012, 5-20.
Kamisan, F. H., Yahya, F., Ismail, N. A., Din, S. S., Mamat, S. S., Zabidi, Z., & Zakaria, Z. A. (2013). Hepatoprotective activity of methanol extract of Melastoma malabathricum leaf in rats. Journal of Acupuncture and Meridian Studies, 6(1), 52–55.
Karupiah, S., & Ismail, Z. (2014). Thrombocyte counts in mice after the administration of methanolic extract of Melastoma malabathricum. Journal of Coastal Life Medicine, 1(4), 327–329.
Khoo, L. T., Abas, F., Abdullah, J. O., Mohd Tohit, E. R., & Hamid, M. (2014). Anticoagulant activity of polyphenolic-polysaccharides isolated from Melastoma malabathricum L. Evidence-Based Complementary and Alternative Medicine, 2014.
Kumar, V., Bhatt, P. C., Sharma, K., Rahman, M., Patel, D. K., Sethi, N, & Anwar, F. (2016). Melastoma malabathricum Linn attenuates complete freund’s adjuvant-induced chronic inflammation in Wistar rats via inflammation response. BMC complementary and alternative medicine, 16(1), 510.
Kumar, V., Ahmed, D., Gupta, P. S., Anwar, F., & Mujeeb, M. (2013). Anti-diabetic, anti-oxidant and anti-hyperlipidemic activities of Melastoma malabathricum Linn. leaves in streptozotocin induced diabetic rats. BMC Complementary and Alternative Medicine, 13(1), 222.
Lohézic-Le Dévéhat, F., Bakhtiar, A., Bézivin, C., Amoros, M., & Boustie, J. (2002). Antiviral and cytotoxic activities of some Indonesian plants. Fitoterapia, 73(5), 400–405.
Mamat, S. S., Kamarolzaman, M. F. F., Yahya, F., Mahmood, N. D., Shahril, M. S., Jakius, K. F., & Zakaria, Z. A. (2013). Methanol extract of Melastoma malabathricum leaves exerted antioxidant and liver protective activity in rats. BMC Complementary and Alternative Medicine, 13(1), 326.
Manicam, C., Abdullah, J. O., Rahayu, E., Tohit, M., Seman, Z., Chin, C., & Hamid, M. (2010). In vitro anticoagulant activities of Melastoma malabathricum Linn. aqueous leaf extract : A preliminary novel finding. Journal of Medicinal Plants, 4(14), 1464–1472.
Manicam, C., Teng, L. K., Ong, J. A., Rahayu, E. M. T., Seman, Z., Sieo, C. C., & Hamid, M. (2013). Subacute Toxic Effects of Melastoma malabathricum Linn. Aqueous leaf extract on liver and kidney histopathology of rats. International Journal of Pharmacology, 9(6), 358–365.
Napisah, H., Azmahani, A., Zubaidah, A., L. Intan, A., & Nazifah, A. (2011). A preliminary study on the antimicrobial properties of several plants collected from Terengganu, Malaysia. Journal of Agrobiotechnology, 2, 99–106.
Nazlina, I., Norha, S., Noor Zarina, A. W., & Ahmad, I. B. (2008). Cytotoxicity and antiviral activity of Melastoma Malabathricum extracts. Journal of the Malaysian Society of Applied Biology, 37(2), 53–55.
Nishanthini, A., Balamurugan, K., & Mohan, V. R. (2013). Evaluation of hepatoprotective and antioxidant activity of Melastoma. International Journal of Current Pharmaceutical Research, 5(1), 33–41.
Nurdiana, S., & Marziana, N. (2013). Wound healing activities of Melastoma malabathricum leaves extract in sprague dawley rats. International Journal of Pharmaceutical Sciences Review and Research, 20(2), 20–23.
Olaleye, M. T., & Rocha, B. J. (2008). Acetaminophen-induced liver damage in mice: effects of some medicinal plants on the oxidative defense system. Experimental and Toxicologic Pathology, 59(5), 319-327.
Ong, H. C., & Norzalina, J. (1999). Malay herbal medicine in Gemencheh, Negri Sembilan, Malaysia. Fitoterapia, 70(1), 10–14.
Rajenderan M. T. (2010). Ethno medicinal uses and antimicrobial properties of Melastoma malabathricum . SEGI Review, 3(2), 34–44.
Sheela, D. A., Rajkumar, J., Modilal, M. R. D., & Ilayaraja, R. (2012). Antimicrobial activities of Avicennia marina, Caesalpinia pulcherrima and Melastoma malabathricum against clinical pathogens isolated from UTI. International Journal of Pharma and Bio Sciences, 3(3), 698–705.
Sirat, H. M., Susanti, D., Ahmad, F., Takayama, H., & Kitajima, M. (2010). Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L. Journal of Natural Medicines, 64(4), 492–495.
Sulaiman, M. R., Somchit, M. N., Israf, D. A., Ahmad, Z., & Moin, S. (2004). Antinociceptive effect of Melastoma malabathricum ethanolic extract in mice. Fitoterapia, 75(7), 667–72.
Sunilson, A., James, J., Thomas, J., Jayaraj, R, V., & Muthappan, M. (2008). Antibacterial and wound healing activities of Melastoma malabathricum Linn. African Journal of Infectious Diseases, 2(2), 68–73.
Sunilson, J. A. J., Anandarajagopal, K., Kumari, A. V. A. G., & Mohan, S. (2009). Antidiarrhoeal activity of leaves of Melastoma malabathricum Linn. Indian Journal of Pharmaceutical Sciences, 71(6), 691–695.
Susanti, D., Sirat, H. M., Ahmad, F., & Ali, R. M. (2008). Bioactive constituents from the leaves of Melastoma malabathricum L. Jurnal Ilmiah Farmasi, 5(1), 1–8.
Susanti, D., Sirat, H. M., Ahmad, F., Ali, R. M., Aimi, N., & Kitajima, M. (2007). Antioxidant and cytotoxic flavonoids from the flowers of Melastoma malabathricum L. Food Chemistry, 103(3), 710–716.
Suteky, T., & Dwatmadji T. (2011). Anthelmintic activity of Melastoma malabatricum extract on Haemonchus contortus activity in vitro. Asian Journal of Pharmaceutical and Clinical Research, 4, 68–70.
Thatoi, H., Panda, S., Rath, S., & Dutta, S. (2008). Antimicrobial activity and ethnomedicinal uses of some medicinal plants from similipal biosphere reserve, orissa. Asian Journal of Plant Sciences, 7(3), 260 – 267.
Verma, A., Bhatt, P. C., Sethi, N., Rashid, M., Singh, Y., Rahman, M., ... & Kumar, V. (2016). Chemomodulatory effect Melastoma Malabathricum Linn against chemically induced renal carcinogenesis rats via attenuation of inflammation, oxidative stress, and early markers of tumor expansion. Inflammopharmacology, 24(5), 233-251.
Wong, K.-C., Hag Ali, D. M., & Boey, P.-L. (2012). Chemical constituents and antibacterial activity of Melastoma malabathricum L. Natural Product Research, 26(7), 609–618.
Yoshida, T., Nakata, F., Hosotani, K., Nittaa, A., & Okudat, T. (1992). Dimeric hydrolysable tannins from Melastoma malabathricum. International Journal of Plant Biochemistry, 31(8), 2829–2833.
Zabidi, Z., Wan Zainulddin, W. N., Mamat, S. S., Shamsahal Din, S., Kamisan, F. H., Yahya, F., Ismail, N. A., & Zakaria, Z. A. (2012). Antiulcer activity of methanol extract of Melastoma malabathricum leaves in rats. Medical Principles and Practice, 21(5), 501–503.
Zahi, A. K., Hamzah, H., Shaari, M. R., Widodo, R. T., Johnny, L., Noordin, M. M., & Sithambaram, S. (2017). Investigation and evaluation of acute and sub-acute dermal toxicity studies of ethanolic leaves extract of Melastoma malabathricum in Sprague Dawley rats. Int. J. Curr. Res. Med. Sci, 3(5), 84-99.
Zainulddin, W., Noraziemah, W., Zabidi, Z., Kamisan, F. H., Yahya, F., Ismail, N. A. & Mohtarrudin, N. (2016). Anti-ulcer activity of the aqueous extract of Melastoma malabathricum L. leaf in rats. Pakistan journal of pharmaceutical sciences, 29(1).
Zakaria, Z. A., Zainol, A. S. N., Sahmat, A., Salleh, N. I., Hizami, A., Mahmood, N. D., & Abdul Hamid, S. S. (2016). Gastroprotective activity of chloroform extract of Muntingia calabura and Melastoma malabathricum leaves. Pharmaceutical biology, 54(5), 812-826.
Zakaria, Z. A., Raden, M. N. R. N. S., Hanan, K. G., Abdul, G. Z. D. F., Sulaiman, M. R., Rathna, D. G., & Fatimah, C. A. (2006a). Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals. Canadian Journal of Physiology and Pharmacology, 84(12), 1291–1299.
Zakaria, Z. A., Rofiee, M. S., Mohamed, A. M., Teh, L. K., & Salleh, M. Z. (2011). In vitro antiproliferative and antioxidant activities and total phenolic contents of the extracts of Melastoma malabathricum leaves. Journal of Acupuncture and Meridian Studies, 4(4), 248–256.
Zakaria, Z. A., Raden, M. N. R. N. S., Sulaiman, M. R., Abdul, G. Z. D. F., Hanan, K. G., Sulaiman, M. R., & Fatimah, C. A. (2006b). Antinociceptive and anti-inflammatory properties of Melastoma malabathricum leaves chloroform extract in experimental animals. Journal of Pharmacology and Toxicology, 1(4), 337-345.