Utilization of Nonsteroidal Anti-Inflammatory Drugs Among Physicians in General Outpatient Unit of University of Ilorin Teaching Hospital, Ilorin

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M. O. Jamiu
A. Giwa
K. Abu-Saeed

Résumé

Nonsteroidal anti-inflammatory drugs are medications used to relieve pain, fever and inflammation. Serious toxicity related to gastrointestinal tract, kidney, dermatological and spontaneous abortion during early pregnancy are of serious concern in their use. The study evaluated the utilization of nonsteroidal anti-inflammatory drugs among prescribers at General Outpatient Department of the University of Ilorin Teaching Hospital. Retrospective study of 1297 patient prescription sheets was carried out at General Outpatient Department of the University of Ilorin Teaching Hospital for a period of six months to evaluate prescribing pattern of nonsteroidal anti-inflammatory drugs by Physicians. Data obtained were analyzed using Statistical Package for Social Science. Data were presented in the form of text, frequency tables, bar chart and pie chart. Inferential statistics was done using logistic regression and chi square. Out of 1497 prescription sheets studied, 1297 contained NSAIDs, giving prescribing rate of 86.6%. About 7.3% of prescriptions contained more than one NSAID. The percentage of generic prescribing was found to be 45%. About 17% of the prescribed NSAIDs were of long time use with only 0.04% co-prescribed with gastro-protective agent, omeprazole or misoprostol. Diclofenac tablet was the most prescribed NSAID with 42.2% prescribing rate. There was no significant difference in duration of prescribed NSAIDs and number of prescribed medicines per prescription in relation to patient’s gender. The prescribing rate of nonsteroidal anti-inflammatory drugs was high with associated multiple NSAIDs use. Diclofenac tablet was the most widely prescribed. Co-prescribing of nonsteroidal anti-inflammatory drugs with gastro-protective agents was found to be very low.

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Jamiu , M. O., Giwa, A., & Abu-Saeed , K. (2020). Utilization of Nonsteroidal Anti-Inflammatory Drugs Among Physicians in General Outpatient Unit of University of Ilorin Teaching Hospital, Ilorin. Nigerian Journal of Pharmaceutical and Applied Science Research, 6(2), 81–87. Consulté à l’adresse https://nijophasr.net/index.php/nijophasr/article/view/192
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M. O. Jamiu

Department of clinical pharmacy and pharmacy practice, Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, Nigeria.

A. Giwa

Department of clinical pharmacy and pharmacy practice, Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, Nigeria.

K. Abu-Saeed

Research Unit, Peace Standard Pharmaceuticals, Ilorin, Nigeria.

Références

Abebe W (2008). Herbal medication: potential for adverse interactions with analgesic drugs. Journal of Clinical Pharmacy and Therapeutics 27(6): 391–401.

Abraham NS, El-Serag HB, Johnson ML, Hartman C, Richardson P, Ray WA, Smalley W (2005). “National adherence to evidence-based guidelines for the prescription of nonsteroidal anti-inflammatory drugs,”Gastroenterology 129 (4): 1171–1178..

Akande TM, Ologe M, Medubi GF (2009). Antibiotic prescription pattern and cost at University of Ilorin Teaching Hospital, Ilorin, Nigeria. International Journal of Tropical medicine 4(2): 50-54.

Berardi RR and Welage LS (2005). Petic Ulcer Diseases In: Pharmacotherapy: A Pathophysiologic Approach 6th ed. DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM (eds); McGraw-Hill, New York. pp 275-279

Bushra R, Aslam N (2010). An Overview of Clinical Pharmacology of Ibuprofen Oman Med J. 25(3): 155–1661.

Catella-Lawson F, Reilly MP, Kapoor SC (2001). Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N. Engl. J. Med. 345:1809-1817.

Cavazos JM, Naik AD, Woofter A, Abraham NS (2008). “Barriers to physician adherence to nonsteroidal antiinflammatory drug guidelines: a qualitative study,”Alimentary Pharmacology and Therapeutics 28 (6): 789–798.

Cheetham TC, Levy G, Niu F, Bixle FR (2009). Gastrointestinal safety of nonsteroidal antiinflammatory drugs and selective cyclooxygenase-2 inhibitors in patients on warfarin. Annals of Pharmacotherapy 43(11): 1765–1773.

Chowdhury SS, Hasan M, Rahman KJ, Waheed TB (2012). Study on the use pattern of NSAIDs in some General and specialized hospitals of Bangladesh. International research journal of Pharmacy: 2012; 3(2): 152-155.

Collier J (1988). The cases for and against prescribing generic drugs: generic prescribing benefits patient. BMJ297: 1596-1598.

Conaghan P.G (2012). A turbulent decade for NSAIDs: update on current concepts of classification, epidemiology, comparative efficacy, and toxicity, Rheumatol Int 32:1491–1502.

Crowe SE, Feldman M, Grover S (2015). Grover S. Patient information: Peptic ulcer disease (Beyond the Basics) available online at https://www.uptodate.com/contents/peptic-ulcer-disease-beyond-the-basics assessed last on15/11/20116.

Cryer B (2005). NSAID-Associated Deaths: The Rise and Fall of NSAID-Associated GI Mortality. The American Journal of Gastroenterology (2005) 100, 1694–1695.

da Costa BR, Reichenbach S, Keller N, Nartey L, Wandel S, Jüni P, Trelle S (2016) Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis. Lancet. Available online at https://www.pharmacist.com/article/effectiveness-nsaids-treatment-pain-knee-and-hip-osteoarthritis Last assed on the 5th Sept; 2017.

Desalegn AA (2001). Assessment of drug use pattern using WHO prescribing indicators at Hawassa University teaching and referral hospital, south Ethiopia: a cross-sectional study. Postgrad Med J. 77:82-88 doi:10.1136/pmj.77.904.82

Dubois RW, Melmed GY, HenningJM, Laine L (2004). Guidelines for the Appropriate Use of Non-Steroidal Anti-Inflammatory Drugs, Cyclo-Oxygenase-2-Specific Inhibitors and Proton Pump Inhibitors in Patients Requiring Chronic Anti-Inflammatory Therapy. Alimentary Pharmacology & Therapeutics 19(2): 1-5

Gul S, Ayub M (2014). Prevalence of prescribing pattern of more than one NSAID in Pakistan. Journal of Scientific and Innovative Research 3(2): 148-154.

Hunt K, Adamson J, Hewitt C, Nazare I (20011). Do women consult more than men? A review of gender and consultation for back pain and headache. J Health Serv Res Policy 16(2): 108–117

Johnell K, Fastbom J (2008). Concomitant use of gastroprotective drugs among elderly NSAID/COX-2 selective inhibitor users: a nationwide register-based study. Clin Drug Investig. 28(11):687-95.

Kaufman DW, Kelly JP, Wiholm BE (1999). The risk of acute major upper gastrointestinal bleeding among users of aspirin and ibuprofen at various levels of alcohol consumption. American Journal of Gastroenterology 94 (11):3189–3196.

LeResche L (1999). Gender considerations in the epidemiology of chronic pain. In: Crombie IK, Croft PR, Linton SJ, eds. Epidemiology of Pain. Seattle: IASP Press: 43-52

Lewis SC, Langman MJS, J. R. Laporte, JNS, Matthews MD, Wiholm BE (2002). Dose-response relationships between individual nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) and serious upper gastrointestinal bleeding: a meta-analysis based on individual patient data, British Journal of Clinical Pharmacology 54(3): 320–326.

Louie SG, Park B, Yoon H (2003). Biological response modifiers in the management of rheumatoid arthritis. Am. J. Health. Syst. Pharm. 60:346-355.

Ndukwe HC. Ogaji JI, Comfort N (2013). Drug use Pattern with Standard Indicators in Jos University Teaching Hospital Nigeria. West African Post Graduate Journal of Pharmacy 24(1): 88-93

Owusu-Ansah SA (2009). Analgesics use at polyclinic outpatient Department of Komfo Anokye teaching Hospital, A project thesis submitted in partial fulfillment of M.Sc, Pharmaceutical Sciences. Kwame Nkrumah University of Science and Technology, Faculty of Pharmaceutical Sciences. Kumasi.

Richardson J, Holdcroft A. Gender differences and pain medication. Womens Health (Lond). 2009. 5(1):79-90. Available online at ttps://www.ncbi.nlm.nih.gov/pubmed/19102644

Risser A, Donovan D, Heintzman J, Page T (2009). NSAID Prescribing Precautions. Am Fam Physician. 80(12):1371-1378.

Russell RI (2001). Non-steroidal Anti-inflammatory Drugs and gastrointestinal damage—problems and solutions. Postgrad Med J. 77(904): 82–88.

Saeed MS, Alkhoshaiban AS, Al-Woraf YMA, Long CM (2014). Perception of self-medication among university students in Saudi Arabia. Archives of Pharmacy Practice. 5(4):149.

Sanfélixa J, Palopb V, Rubiod E, Gosalbese V, Martínez-Mirf I (2008). Gender influence in the quantity of drugs used in primary care Gaceta Sanitaria 22(1): 11–19.

Sherazi BA, Mahmood KT, Amin F, Zaka M, Riaz M, Javed A (2012). Prevalence and Measure of Self Medication. Journal of Pharmaceutical Sciences and Research. 4(3): 1774-1778

Soleymani F, Ahmadizar A and Abdollahi MA (2013). Survey on the factors influencing the pattern of medicine's use: Concerns on irrational use of drugs. J Res Pharm Pract.; 2(2), 59–63.

Taylor R, Lemtouni S, Weiss K, Pergolizzi JV (2012). Pain Management in the Elderly: An FDA Safe Use Initiative Expert Panel’s View on Preventable Harm Associated with NSAID. Therapy Current Gerontology and Geriatrics Research.196159:1-9. doi:10.1155/2012/196159

Teslim OA, Vyvienne M, Olatokunbo, OM, Oluwafisayo, AJ, Mlenzana, NB, Shamila M, Nesto M, Grace M (2014). Side effects of non-steroidal anti-inflammatory drugs: The experience of patients with musculoskeletal disorders. Am J Health Res 2: 106-212. Am J Health Res 2: 106-212.

Tulner LR, Frankfort SV Gijsen GJPT, Van Campen PCM, CKoks CHW Beijnen JH (2002). Drug-drug interactions in a geriatric outpatient cohort: prevalence and relevance. Drugs and Aging.25(4): 343–355.

Wells, B G.; DiPiro, JT.; Schwinghammer TL.; Hamilton, CW (2006). Pharmacotherapy Handbook, 6th Edition. McGraw-Hill pp 550-557

World Health Organization (2015). The role of Pharmacists in the health care system: Essential medicines and Health Products Information Portals, Geneva.

World Health Organization (2017). Guide to Good Prescribing. Action Programme on Essential Drugs Geneva available online at http://apps.who.int/medicinedocs/en/d/Jwhozip23e/5.4.html. Last assessed on 5th September 2017.