Material and Tableting Properties of Theophylline Solid Dispersions

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Oluwaseun A. Orugun
Adeniji K. Olowosulu
Olubunmi J. Olayemi
Yonni E. Apeji
Avosuahi R. Oyi
Kenneth C. Ofokansi

Résumé

This study was carried out to evaluate the material and tableting properties of theophylline solid dispersions (SDs) prepared by the solvent evaporation technique using Eudragit polymers (RS 100 & RSPO) as carriers. The dispersions were directly compressed into tablets using microcrystalline cellulose (MCC) as filler/binder. Compatibility studies of the prepared dispersions were conducted using FTIR, DSC and TLC while physicotechnical properties of the tablets were evaluated. Results of compatibility studies revealed no chemical interaction between theophylline and the selected polymers. All the tablet properties evaluated were in conformity with the USP specifications. In vitro drug release was observed to be prolonged for about 24 h and the mechanism of drug release was principally by diffusion. Stability studies showed that drug content of all the tablets remained within the official specifications after three months. Overall, the material properties of the SDs were consistent with good tableting properties as confirmed by the tablets produced.

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Orugun, O. A. ., Olowosulu, A. K. ., Olayemi, O. J. ., Apeji, Y. E. ., Oyi, A. R. ., & Ofokansi, K. C. . (2020). Material and Tableting Properties of Theophylline Solid Dispersions. Nigerian Journal of Pharmaceutical and Applied Science Research, 6(1), 43–51. Consulté à l’adresse https://nijophasr.net/index.php/nijophasr/article/view/164
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Bibliographies de l'auteur-e

Oluwaseun A. Orugun

Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria

Adeniji K. Olowosulu

Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria

Olubunmi J. Olayemi

Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development (NIPRD), Idu, Abuja

Yonni E. Apeji

Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria

Avosuahi R. Oyi

Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria

Kenneth C. Ofokansi

Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria.

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