Comparison Of Microbiological And Chemical Assay Methods Used In The Quality Assessment Of Ampicillin Suspensions Sold In Zaria-Nigeria
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Résumé
There appears to be a disagreement between chemists and biologists over which of the methods for the assay of antibiotics is better and more reliable. A total of 27 samples of ampicillin suspension from three different companies comprising nine batches and sold within Zaria-Nigeria were therefore assayed to determine their potency using standard chemical and microbiological methods. Results obtained showed that most of the products were of acceptable quality and also confirmed that each of the two methods compared was as good as the other and can therefore be used for the determination of the quality of ampicillin.
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Références
AHFS Drug information 2006 (2006 ed.) America society of health system pharmacists British Pharmacopeia (2011). The Stationary office, London
Cazedey, E. C. L and Salgado, H. R. N (2011). Development and validation of microbiological assay for the determination of Orbifloxacin in pharmaceutical preparation. Pharmaceutics 3, 572-581
Dale, M.M; Rang, H.P and Maureen M. Dale (2007). Rang and Dale s Pharmacology Edinburgh: Churchhill Livingstone 6th ed.
Hewitt, W (2003): Microbiological assay for Pharmaceutical analysis: A rational approach. Liandysul, UK. CRCR press, 1-20
Hodges, N. A. (2001) Pharmaceutical applications of microbiological techniques in Pharmaceutics, The science of dosage form design by M. E. Aulton 9th ed. Churchill Livingstone, London 623-643.
Li, N; Miles M. V; Hall, W; Carson, S.W (1995). An improved micromethod for vancomycin determination by high performance liquid chromatography. Ther. Drug Monit. 17:366-370.
Nishant, A Dafale, Utam P. Semwal, Piyush K. Agarwal, Pradeep Sharma, G.N. Singh (2014). Development and validation of microbial bioassay for quantification of levofloxacin in pharmaceutical preparation. J Pharm Anal. 5:18-26.
Pinto, T.J.A., Laurenco F. R.,kaneko, T. M (2007). Microbiological assay of Gentamycin employing an alternative experimental design. In: AOAC Annual meeting and exposition 121, Anais. Anahein- California. 157.
Udobi, Chinweizu Ejikeme and Otudor Chidiebere (2014). Effect of storage on the time kill qualities of ampicillin. Int. J. Curr. Microbiol. App.Sci. 3(8) 886-893.
Udobi, Chinweizu Ejikeme and Onaolapo Josiah Ademola (2010). Microbiological assay of the activecomponent of ampicillin in ampicillin and ampicillin/cloxacillin suspensions using Bacillus megatharium NCTC 10342A76 as indicator organism. Afri. Jour. Microb. Res. 4 (1): 051-054.
United States Pharmacopeia (2009). United States Pharmacopeia convention, Rockville, M.D, USA.