Antinociceptive and Antipyretic activity of leaf extract of <em>Lasianthera Africana</em>
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Abstract
The leaf of Lasianthera africana is used commonly for nutritional purposes and medicinally in the treatment of fever, malaria and inflammatory diseases. The ethanol leaf extract of Lasianthera africana (500 - 1500 mg/kg) was evaluated for analgesic and antipyretic activities against acetic acid-induced writhing, formalin-induced hind paw licking, thermal – induced pain, amphetamine and yeast - induced pyrexia models. The dichloromethane fraction was also analyzed using Gas chromatography-mass spectrometry (GCMS). The leaf extract exhibited a dose-dependent inhibition of pains in the three experimental models and significant (p<0.01) inhibition of pyrexia induced by amphetamine and yeast. The GCMS analysis revealed the presence of pharmacologically active compounds which are likely responsible for the observed activities suggesting that the leaf extract possess analgesic and antipyretic properties.
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