Hepatocellular and renal effect of Gongronema Latifolium leaf extract on Albino rat following acetylaminophen (Paracetamol) poisoning

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Nosa T Omorodion
Aniobi C Chukwubuikem
Uwadiegwu P Achukwu
Barisuka K Nwibana

Abstract

Background: Gongronema latifolium  has been known over the years to serve as cancer preventing agent. The Effect of Gongronema latifolium leaf Extract on Renal and Hepatic tissue of Albino Rat following Acetaminophen (paracetamol) Poisoning was analyzed in this study.


Methods: Twenty eight rats were randomly selected and shared into seven groups of four rats per cage and labeled A,B,C,D,E,F, and G. Cages A, B and C served as both baseline (positive control, and negative control) while group D to G serve as treatment groups (they were treated with both leaf extract in order of 6,12,18 and 24mg/kg weight and 250mg/ml of paracetamol with regards to the LD50. The animals were fed with standard pellet and tap water for 28 days. The doses were orally administered for 28 days. On day 28, the rats were weighed, sacrificed by cranial dislocation, and the liver and the kidney were harvested. The liver and kidney were processed, stained for light microscopy.


Results: Histology of the liver and kidney showed few areas of cystically dilated tubules, focal infiltration of inflammatory cells, mild dilation, extensive tubular dilation , hepatic cytoplasmic clearing, periportal inflammation. Conclusion: This research therefore demonstrated that Gongronema latifolium  leaf extract has antioxidative property that enables gradual repair of damaged tissues possible.

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T Omorodion, N., C Chukwubuikem , A. ., P Achukwu , U. ., & K Nwibana, B. . (2021). Hepatocellular and renal effect of Gongronema Latifolium leaf extract on Albino rat following acetylaminophen (Paracetamol) poisoning. Nigerian Journal of Pharmaceutical and Applied Science Research, 10(2), 21-27. Retrieved from https://nijophasr.net/index.php/nijophasr/article/view/435
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