Bioactive constituents and antiulcer activity of the unripe fruit peel of Musa Paradisiaca L. (Musaceae)
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Abstract
Background: Musa paradisiaca is used traditionally in treating diarrhoeal, wounds and infections and also in the management of diabetics and ulcer. This work aimed to evaluate the proximate contents, phytochemical constituents and the antiulcer potential of the peel of Musa paradisiaca.
Methods: Proximate parameters and phytochemical constituents was evaluated using standard procedures and gas chromatography-mass spectrometry (GC-MS), while the effect of the extract on ethanol induced stomach ulcer was study in adult Wister rats.
Results: Result revealed ash value (8.70 ± 0.50) %, crude fibre (10.50 ± 0.70) % and moisture content (20.30 ± 0.40) % respectively. Phytochemicals present included alkaloids, tannins, flavonoids, triterpenoids, steroids and saponins. GC-MS analysis identified twenty-three compounds including gamma tocopherol. The methanol extract exhibited significant antiulcer activity at 400 mg/kg and its activity increases as the dose increases.
Conclusion: The study showed that Musa paradisiaca contains important phytoconstituents and validated the ethno-medicinal claim of antiulcer effect.
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