Anticonvulsant activity of leaf extract of Heinsia crinata BIOLOGICAL ACTIVITY OF HEINSIA CRINATA

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Published: Mar 31, 2021
Keywords:
HEINSIA CRINATA, ANTICONVULSANT, VEGETABLE

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Jude Okokon
Department of Pharmacology and Toxicology, University of Uyo
Koofreh Davies
DEPT OF PHARMACOLOGY AND TOXICOLOGY, UNIVERSITY OF UYO
Utibe A. Edem
DEPT OF PHARMACOLOGY AND TOXICOLOGY, UNIVERSITY OF UYO
Augustine I. Bassey
UNIVERSITY OF UYO, UYO, NIGERIA

Abstract

Background: Heinsia crinata(Afzel). G. Tayl. (Rubiaceae), is used in Ibibio ethnomedicine for the treatment of various diseases such as CNS disorders. The anticonvulsant activity of the leaf extract was studied.


Method: The ethanol leaf extract of H. crinata (450-1350 mg/kg) was investigated for anticonvulsant activity in mice against pentylenetetrazol, aminophylline and isoniazid-induced convulsion models to assess anticonvulsant activity.


Results: The extract was found to significantly (p<0.005-0.01) and dose-dependently offered protection against PTZ-, aminophylline and isoniazid-induced convulsions in mice.


Conclusion: The leaf extract of H. crinata possess anticonvulsant activity and this supports its use in ethnomedicine for the treatment of central nervous system disorders.

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Okokon, . J., Davies, K. ., Edem, U. A. ., & Bassey, A. I. . (2021). Anticonvulsant activity of leaf extract of Heinsia crinata : BIOLOGICAL ACTIVITY OF HEINSIA CRINATA. Nigerian Journal of Pharmaceutical and Applied Science Research, 10(1), 20–25. Retrieved from https://nijophasr.net/index.php/nijophasr/article/view/414
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Vol. 10 No. 1 (2021): Nigerian Journal of Pharmaceutical and Applied Science Research (NIJOPHASR)
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