Anticonvulsant activity of leaf extract of Heinsia crinata BIOLOGICAL ACTIVITY OF HEINSIA CRINATA

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Jude Okokon
Koofreh Davies
Utibe A. Edem
Augustine I. Bassey


Background: Heinsia crinata(Afzel). G. Tayl. (Rubiaceae), is used in Ibibio ethnomedicine for the treatment of various diseases such as CNS disorders. The anticonvulsant activity of the leaf extract was studied.

Method: The ethanol leaf extract of H. crinata (450-1350 mg/kg) was investigated for anticonvulsant activity in mice against pentylenetetrazol, aminophylline and isoniazid-induced convulsion models to assess anticonvulsant activity.

Results: The extract was found to significantly (p<0.005-0.01) and dose-dependently offered protection against PTZ-, aminophylline and isoniazid-induced convulsions in mice.

Conclusion: The leaf extract of H. crinata possess anticonvulsant activity and this supports its use in ethnomedicine for the treatment of central nervous system disorders.


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Okokon, . J., Davies, K. ., Edem, U. A. ., & Bassey, A. I. . (2021). Anticonvulsant activity of leaf extract of Heinsia crinata : BIOLOGICAL ACTIVITY OF HEINSIA CRINATA. Nigerian Journal of Pharmaceutical and Applied Science Research, 10(1), 20-25. Retrieved from


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