Determination of Aspirin Stability in oil in Water Emulsion prepared using different oils and Gums.
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Abstract
The poor stability of aspirin in aqueous medium is a major drawback in the formulation of aspirin in liquid dosage form. This study is aimed at formulating stable oil preparation of aspirin with okra (Abelmoschus esculentus L) mucilage as emulsifying agent. The emulsion was formulated by dispersing the aspirin in the oily phase which was then dispersed in the aqueous continuous phase. The specific density, pH, organoleptic properties and aspirin content of the emulsions were evaluated. The effect of the okra mucilage was compared to acacia which serve as a standard natural emulsifying agent. Emulsions of acacia gave pH of 3.18, 3.31, and 3.35 compared to those of okra mucilage (O.M) with pH of 3.11, 3.10 and 3.06. The percentage content and stability were better in olive oil emulsion compared to emulsions made of palm oil and shea butter. The organoleptic properties of the formulations varied with the viscosity of the oils. This study showed that aspirin and okra mucilage have good compatibility with olive oil, which can serve as a means of formulating aspirin emulsion to enhance compliance in children. O.M can be useful in formulating stable emulsions when combine with other natural emulsifiers in small quantities.
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