@article{D.C Owaba_S. Eboh_C. Ugwoke_Ogbiko_2022, title={Acute Toxicity and Histopathological Evaluation of Seed and Stem Bark Extracts of Carapa procera D.C Meliaceae on Liver and Kidney of Male Wistar Rats}, volume={11}, url={https://nijophasr.net/index.php/nijophasr/article/view/469}, abstractNote={<p>Background: Carapa procera D.C belongs to the family of Meliaceae is a medicinal plant used in the Ijaw area of<br>Niger Delta for the management of diseases; seed for malaria while decotion of stem bark for erectile dysfunction in<br>ethnomedicine. The aim of study is to assess the safety, toxicity on the liver and kidney in order to corroborate and<br>regulate the use in humans.<br>Method: The seed and stem bark were extracted using n-hexane, dichloromethane, and 70% methanol via successive<br>cold maceration. Acute toxicity profile was determined using the Lorke’s method. The LD50 for the crude seed and<br>stem bark extract were determined to be at 866.03 and 447.21 mg/kg. Various doses of the LD50 (10, 20 and 30%)<br>were administered daily to ninety male rats orally for 7 days. On the 8th day it was anaesthetized using chloroform,<br>sacrificed, liver and kidney harvested for histological evaluation.<br>Results: The histological assessment revealed no distortion in organs assessed when compared to control excerpt the<br>high dose crude seed extract which showed signs of toxicity.<br>Conclusion: The crude seed extract at high dose affect the liver due to distortion, steatosis and should not be used<br>while at low and medium dose showed no alteration in the hepatic architecture.</p>}, number={2}, journal={Nigerian Journal of Pharmaceutical and Applied Science Research}, author={D.C Owaba, Azibanasamesa and S. Eboh, Abraham and C. Ugwoke, Emmanuel and Ogbiko, Cyril}, year={2022}, month={Sep.} }