Encapsulated Self-Emulsifying Drug Delivery System of Simvastatin: A Novel Approach for Enhanced Dissolution
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Abstract
Background: The solid form of a self-emulsifying drug delivery system (SEDDS) enhances formulation stability and dissolution. This study aimed to develop an encapsulated self-emulsifying drug delivery system of simvastatin utilizing Tween 80/ethanol mixture as the surfactant/co-surfactant system.
Methods: Two separate 10 mL Tween 80/ethanol mixes (ratios 5:5 and 1:9) were used in formulating Liquid SEDDSs containing 0.1 g simvastatin. Compatibility studies using FTIR spectroscopy and particle size analysis using zeta sizer were carried out. The liquid SEDDSs were adsorbed on microcrystalline cellulose and later encapsulated. In vitro dissolution of the capsules in comparison with a marketed product was carried out.
Results: The observed peaks in the fingerprint region in the spectrum of simvastatin were superimposed in the spectrum of the SEDDS. There was no significant difference in the particle size of simvastatin and the SEDDS. The marketed product released less than 5% of the drug after 120 minutes, whereas the formulated SEDDSs showed a drug release of 32–40% (an increase of over 600%).
Conclusion: The solid SEDDS formulation of simvastatin improves drug delivery compared to the conventional formulation. Additionally, a 5:5 Tween 80/ethanol ratio is superior to a 1:9 ratio for SEDDS formulation
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References
Maji I, Mahajan S, Sriram A, Medtiya P, Vasave R, Khatri DK, Kumar R, Singh SB, Madan J, Singh PK. Solid self-emulsifying drug delivery system: Superior mode for oral delivery of hydrophobic cargos. J Contr Rel. 2021; 337: 646-660.
Singh B, Bandyopadhyay S, Kapil R, Singh R, Katare O. Self-emulsifying drug delivery systems (SEDDS): formulation development, characterization, and applications. Crit Rev Ther Drug Carrier Syst. 2009; 26(5): 427-521.
Gershanik T, Benita S. Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs. Eur J Pharm Biopharm. 2000; 50(1): 179-188.
Salawi A. Self-emulsifying drug delivery systems: A novel approach to deliver drugs. Drug Deliv. 2022; 29(1): 1811-1823.
Joyce P. Synergistic effect of PLGA nanoparticles and submicron triglyceride droplets in enhancing the intestinal solubilisation of a lipophilic weak base. Eur J Pharm Sci. 2018; 118: 40-48.
Ahmed TA. Enhancement of simvastatin bioavailability via ternary solid dispersion with nanoemulsion: in vitro, ex vivo and in vivo assessment. Int J Pharm. 2021; 594: 120-133.
Arora P. In vitro and in vivo evaluation of solid self-emulsifying drug delivery system of simvastatin: development, optimization and pharmacokinetic study. Drug Dev Ind Pharm. 2021; 47(3): 465-475.
Elshamy AA. Novel simvastatin solid self-emulsifying drug delivery system with high oral bioavailability, prolonged hypolipidemic activity and cardiovascular protection: In vitro and in vivo evaluation. Int J Pharm. 2021; 606: 120-169.
Kang BK, Lee JS, Chon SK, Jeong SY, Yuk SH, Khang G, Lee HB, Cho SH. Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. Int J Pharm. 2004; 274(1-2): 65-73.
Olorunsola EO, Bhatia PG, Tytler BA, Adikwu MU. Compatibility study of cashew and prosopis gums with some artemisinins. Nig J Pharm. 2016; 50(2): 35-53.
Bashir MA, Khan A, Shah SI, Ullah M, Khuda F, Abbas M, Gok KW, Ming LC. Development and evaluation of self-emulsifying drug-delivery system–based tablets for simvastatin, a BCS class II drug. Drug Des Devel Ther. 2023; 17: 261-272.
Lavra ZMM, Pereira de Santana D, Ré MI. Solubility and dissolution performances of spray-dried solid dispersion of efavirenz in soluplus. Drug Dev Ind Pharm. 2017; 43: 42–54.
Saleem MA, Yasir Siddique M, Nazar MF, Khan SU, Ahmad A, Khan R, Hussain SZ, Mat Lazim A, Azfaralariff A, Mohamed M. Formation of antihyperlipidemic nano-ezetimibe from volatile microemulsion template for enhanced dissolution profile. Langmuir 2020; 36(27): 7908-7915.
Essien ES, Jackson TC, Olorunsola EO. Development and evaluation of encapsulated self-emulsifying drug delivery system of hydrochlorothiazide. Nig J Pharm Res. 2024; 20(1): 23-30.