Antimalarial effects of ethanol leaf extract and fractions of Peristrophe bicalyculata in mice

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Uwemedimo F. Umoha
Danladi N. Balaa
Samuel J. Offora
Chimezie Osualaa

Abstract

The leaf infusion of Peristrophe bicalyculata (RETZ) NEES (Acanthaceae) is a commonly used remedy in the treatment of malaria by the Ibibio indigenes of Akwa Ibom State of Nigeria. The antimalarial effects of ethanol leaf extract and fractions of Peristrophe bicalyculata (RETZ) NEES (Acanthaceae) were investigated in mice infected with Plasmodium berghei berghei
during early and established infections using suppresive, repository and curative animal experimental models. Peristrophe bicalyculata extract and fractions (374 – 1123 mg/kg/day) exhibited a significant (P<0.05) blood schizonticidal activity both in 4 day early infection and in established infection. The leaf extract and fractions possessed promising antiplasmodial activities
which could be exploited in malaria therapy.

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How to Cite
Umoha, U. F., Balaa, D. N. ., Offora, S. J. ., & Osualaa, C. . (2014). Antimalarial effects of ethanol leaf extract and fractions of Peristrophe bicalyculata in mice. Nigerian Journal of Pharmaceutical and Applied Science Research, 3(1), 24–31. Retrieved from https://nijophasr.net/index.php/nijophasr/article/view/49
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Articles
Author Biographies

Uwemedimo F. Umoha

Department of Pharmacognosy and Natural Medicine, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria.

Danladi N. Balaa

Department of Pharmacognosy and Natural Medicine, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria

Samuel J. Offora

Department of Pharmacognosy and Natural Medicine, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria.

Chimezie Osualaa

Department of Pharmacognosy and Natural Medicine, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria

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