Antimalarial effects of ethanol leaf extract and fractions of Peristrophe bicalyculata in mice
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Abstract
The leaf infusion of Peristrophe bicalyculata (RETZ) NEES (Acanthaceae) is a commonly used remedy in the treatment of malaria by the Ibibio indigenes of Akwa Ibom State of Nigeria. The antimalarial effects of ethanol leaf extract and fractions of Peristrophe bicalyculata (RETZ) NEES (Acanthaceae) were investigated in mice infected with Plasmodium berghei berghei
during early and established infections using suppresive, repository and curative animal experimental models. Peristrophe bicalyculata extract and fractions (374 – 1123 mg/kg/day) exhibited a significant (P<0.05) blood schizonticidal activity both in 4 day early infection and in established infection. The leaf extract and fractions possessed promising antiplasmodial activities
which could be exploited in malaria therapy.
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References
Burkill, HM (1996). The Useful Plants of West Tropical Africa, Families A-D. Royal Botanic Gardens, Kew. Vol. 3, Pp. 320 - 323.
Clark, SB (2002). Antimalarial Natural Products. Isolation, Characterization and Biological Properties. Taylor and Francis, London. Pp. 379 -432.
Knight, D. J. and Peters, W. (1980). The antimalarial action of N-benzyloxydihydrotriazines and the studies on its mode of action. Annals of tropical medicine and parasitology. 74:393-401.
Kirby, G. C., O’Neil, M. J., Philipson, J. D. and Warhurst, D. C. (1989). In vitro studies on the mode of action of quassinoids with activity against chloroquine resistant Plasmodium falciparum. N Engl J. Med. 38: 4367 – 4374.
Lorke, D. (1983). A new approach to practical acute toxicity testing. Archives of Toxicology 54: 275-286.
Peters, W. (1965). Drug resistance in Plamodium berghei. Experimental parasitology. 17:80-89.
Philipson, J. D. and Wright, C. W. (1991). Antiprotozoal compounds from plants sources. Planta Med. 57; 553 – 559.
Richard, D (2006). Malaria Mosquito Anopheles gambiae. Science 241: 115-119.
Ryley, J. F. and Peters, W. (1970). The antimalarial activity of some quinolone esters. Annals of Tropical Medicine and Parasitology. 84:209- 222.
Trease, G. E. and Evans, W. C. (1999). Pharmacognosy, 13th ed, Bailliere Tindal, London, Pp. 225-255.