Formulation and evaluation of effect of mucilage of Corchorus olitorius leaves on antioxidant activity of Spondias mombin extract

Main Article Content

Joseph O. Oiseoghaede
Aminat A. Oyawaluja
Olukemi A. Odukoya
Margaret O. Ilomuanya
Omotayo K. Raji

Abstract

Background: Mucilage from medicinal plants such as Corchorus olitorius L. (Malvaceae) can serve as alternative
sources of suspending agents as currently commercially available ones are quite costly. However, they may also affect
formulation characteristics and activity of final product. This study evaluated effect of mucilage of Corchorus olitorius
L. (Malvaceae) leaves on antioxidant activity of aqueous fraction of hydroethanolic extract of Spondias mombin L.
(Anacardiaceae) leaves.


Methods: Standard in vitro antioxidant assays were used. Mucilage was investigated for its phytochemical contents.
Physico-chemical evaluation using pH meter and microscopical characterization emulsion were also carried out.
Repeated measures analysis of variance (ANOVA) was used to compare activity of extract versus emulsion.
Results: Terpenoids, unsaturated lactones, carbohydrates and reducing sugars were present in the mucilage. The stable
emulsion formulated had a pH of 6.7 with oil droplets of average size, 9.12µm. Most droplets were small size. The
extract had superior 2,2-diphenyl-1-picrylhydrazyl radical inhibition, hydrogen peroxide radical inhibition and
reducing capacity (? = 0.05) but emulsion had better metal chelating activity (? = 0.05).


Conclusion: The mucilage significantly reduced antioxidant activity in the emulsion but could be used orally for
indicated oxidative conditions.

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How to Cite
Oiseoghaede, J. O. ., Oyawaluja, A. A. ., Odukoya, O. A. ., Ilomuanya, M. O. ., & Raji, O. K. . (2021). Formulation and evaluation of effect of mucilage of Corchorus olitorius leaves on antioxidant activity of Spondias mombin extract. Nigerian Journal of Pharmaceutical and Applied Science Research, 10(2), 33-40. Retrieved from https://nijophasr.net/index.php/nijophasr/article/view/443
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Author Biographies

Joseph O. Oiseoghaede

Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, College of Medicine of the University of Lagos campus, Idi-Araba, Lagos.

Aminat A. Oyawaluja

Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, College of Medicine of the University of Lagos campus, Idi-Araba, Lagos.

Olukemi A. Odukoya

Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, College of Medicine of the University of Lagos campus, Idi-Araba, Lagos.

Margaret O. Ilomuanya

Department of Pharmaceutics and Pharmaceutical technology, Faculty of Pharmacy, University of Lagos, College of Medicine of the University of Lagos campus, Idi-Araba, Lagos

Omotayo K. Raji

Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, College of Medicine of the University of Lagos campus, Idi-Araba, Lagos.

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