Formulation of subcutaneous implantable drug delivery system of ibuprofen using biodegradable polymers

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Collins Airemwen
Isesele E. Jude
Adaeze P. Uchendu
Emmanuel M. Halilu
Michael U. Uhumwangho

Abstract

Background: The purpose of this study was to formulate subcutaneous implantable drug delivery system of ibuprofen using biodegradable polymers and to evaluate the formulated implants using in vitro and in vivo models.


Method: The solvent casting technique was used in the formulation of the implants with gelatin-hydroxypropyl methylcellulose (HPMC) admixture (80:20) as the polymer blend. The plasticizing agent used was glycerin. The physicochemical properties of the implants were evaluated. The implants in vivo analgesic effect on acetic acid-induced mouse writhing in mice was also investigated.


Results: The implant pellets were similar in appearance with minimal variation from batch to batch. The mean diameter/thickness of the implants ranged from 2.60 ± 0.10 - 2.85 ± 0.20 mm, the mean percentage drug content was 96.40 ± 0.10% and the swelling index values were 2.98 ± 0.12 – 4.86 ± 0.11%. In comparison to the control, the in vivo analgesic effect of the ibuprofen implants significantly reduced acetic acid-induced writhing in mice.


Conclusion: The results of this study demonstrated that the solvent casting technique can be used in the formulation of ibuprofen biodegradable implants that can be used in the management of chronic diseases such as arthritis.

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How to Cite
Airemwen, C., E. Jude, I. ., P. Uchendu, A. ., M. Halilu , E. ., & U. Uhumwangho, M. . (2022). Formulation of subcutaneous implantable drug delivery system of ibuprofen using biodegradable polymers. Nigerian Journal of Pharmaceutical and Applied Science Research, 10(4), 14–21. Retrieved from https://nijophasr.net/index.php/nijophasr/article/view/430
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References

Isesele JE, Airemwen CO, Uchendu AP, Asemwota IO, Obarisiagbon AJ and Uhumwangho MU. Formulation and in vivo studies of

ibuprofen biodegradable implants, Eur J Pharm and Med Res (2021), 8(7): 58-65.

Rajgor N, Pale M and Bhaskar VH. Implantable Drug Delivery Systems, An Overview Systematic Rev Pharm (2011), 2(2): 91-95.

Alissa R, Sakka S, Oliver R. Influence of Ibuprofen on bone healing around dental implants: a randomized double-blind placebo controlled clinical study. Eur J oral Implant (2009), 2(3):185-199.

Tian H, Tang Z, Zhuang X, Chen X, Jing X. Biodegradable synthetic polymers: preparation, functionalization and biomedical application, Prog Poly Sci (2012), 37: 237- 280.

Mohammed MI, Sanjeev E, Shanti S. Design and evaluation of subcutaneous implantable drug delivery system of tramadol using natural biodegradable polymer, Annals Phytomed (2012), 2:30-38.

Wang CK, Wang WY, Meyer RF, Liang Y, Winey KI, Siegel SJ. A raid method for creating drug implants: Translating laboratory-based methods into a scalable manufacturing process. J Biomed Mater Res (2010), 5(2): 562-572.

Garcia JT, Jesus DM, Mungia O, Llabres M, Farina JB. Biodegradable laminar implants for sustained release of recombinant human growth hormone. J Biomaterials (2002), 23(4): 4759-4764.

Gisele R, Da Silva L, Sílvia LF, Rubens CS, Rodrigo J, Armando-da-Silva CJ. Implants as drug delivery devices for the treatment of eye diseases. Brazilian J Pharm Sci (2010), 46(3): 585-595.

Grosser T, Ricciotti E and FitzGerald GA. The Cardiovascular pharmacology of nonsteroidal anti-inflammatory drugs, A Review. British J Pharm (2017), 172(9): 2152- 2158.

Purushotham RK, Jaybhaye SI, Ravindra K, Bhandari A, Pratima S. Designing of Diclofenac Sodium Biodegradable Drug Implant for Speedy Fracture Healing. J Chem Pharm Res (2010), 3(1) 330-337.

Rao KP, Jaybhaye SJ, Ravindra K, Anil B, Pratima S. Designing of Diclofenac Sodium Biodegradable Drug Implant for Speedy Fracture Healing. J Chem Pharm Res (2010), 3(1) :330-337.

Kanzaria R, Kapadia Y, Lalji B, Desai TR. Implant - controlled release medicated formulation. Int J Pharm and Chem Sci (2012), 1(1):59- 66.

Onishi HM, Takahashi N and Machinda Y. PLGA implant tablet of ketoprofen: comparison of in vitro and in vivo releases. Biol Pharm Bull (2005), 28(10): 2011-2015.

Higuchi T. Mechanism of sustained action medication. Theoretical analysis of rate release of solid drugs dispersed in solid matrices. J. Pharm. Sci (1963), 52: 1145-1149.

Korsemeyer RW, Gurny R, Doelker EM, Buri P and Peppas NA. Mechanism of solute release from porous hydrophilic polymers, Int J Pharm (1983), 15: 25-35.

Koster R, Anderson M, De Beer EJ. Acetic acid-induced analgesic screening. Federation proceedings (1959), 18:412-417.

Oalta R, Grewal Y, Batth S, Singh A. A Survey of analgesic and anti-inflammatory drug prescription for oral implant surgery. Int J Plastic and Aesthetic Res (2015), 2: 51-55.

British Pharmacopoeia (2012). London, UK: Her Majesty’s Stationery Office: A234.

Michael NP, Yogeshvar NK, Michael H and Michael SR. Transdermal patches: history, development and pharmacology. British J Pharm (2015), 172(9): 2179- 2190.

Satish CS. Formulation and Evaluation of a Chitosan-PVA-gellan insulin implant, Int J App Pharm (2017), 9(3): 37-41.

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