Determination of Oral Glucose Tolerance (OGT) of Benign Prostatic Hyperplasia Patients Treated with Tamsulosin in Sokoto State, Nigeria
Article Sidebar
Main Article Content
Abstract
This study determined the effect of tamsulosin on blood glucose tolerance among patients of benign prostatic hyperplasia/ lower urinary tract symptoms in Sokoto state, Nigeria. Standard methods were used in this study.The result revealed a significant increase (P<0.05) in the area under oral glucose tolerance test (OGTT) curve at 2nd month,3rd month, and 4thmonth progressively. Comparisons between mean values at other time points were not significantly different (P>0.05). A change (P<0.05) in the total area under the OGTT curve was observed in BPH patients aged 55-64 years at 4th month compared to the values of the 0th and 1st months. Comparisons between mean values at other time points were not significantly different (P>0.05). At 0th or 1stor 2ndor 3rd or 4th month, there was no significant difference (P>0.05) in the total area under the OGTT curve between the three (3) age groups.The results of the study showed that tamsulosin caused hyperglycemiain BPH patients. It is recommended that blood glucose levels in BPH patients using tamsulosin should be monitored to avoid hyperglycemia complications.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
American Society of Health System Pharmacists (1995). ASHP guidelines on adverse drug reaction monitoring and reporting. American Journal of Health System Pharmacists 52:417-419.
American Urological Association Education Inc.(2010). American Urological Association Guideline: Management of prostatic hyperplasia (BPH).Www.auanet.org.
Arief A, Kleeman CR (2000). Studies on mechanisms of cerebral edema in diabetic comas. Journal of American Society of Nephrology 11:1776-1788.
Bello SO, Umar MT (2011). Knowledge and attitudes of physicians relating to reporting of adverse drug reactions in Sokoto, north-western Nigeria. Annals of African Medicine 10(1):13-8.
Bilbis LS, Muhammad SA, Saidu Y, Adamu Y (2012).Effect of vitamins A, C, and supplementation in the treatment of metabolic syndrome in albino rats. Biochemistry Research International 1-7.
Borgsteede S, Buggeman R, Hoefriagel R, Huiskes M, van Puijenbroek E (2010). Tamsulosin and hyperglycemia in patients with diabetes.The Journal of Medicine 68(3):141-143.
Cheng JT, Liu, IM., Yen ST, Chen PC (2000). Role of alpha1A-adrenoceptor in the regulation of glucose uptake into white adipocyte of rats in vitro. Autonomic Neuroscience : Basic and Clinical 84 (3): 140–6.
Chika A, Onyebuece DC, Bello SO (2018). Phytochemical analysis and evaluation of antidiabetic effects in alloxan-induced diabetic rats treated with aqueous leaf extract of Acanthospermumhispidium. African Research Journal of Biomedical Research 21:81-85.
Chika A, Yahaya A (2019). Efect of coadministration of glibenclamide and methanolic extract of Aniposopusmanii N.E. Br (Apocynaceae) on glucose homestasis and lipid profile in streptocin/ Nicotinamide-induced diabetic rats. National Journal of Physiology, Pharmacy and Pharmacoplogy 9(10):1045-1051.
Dankner R, Chetrit A, Shanik, MH, Raz I, Roth J (2012). Basal state hyperinsulinemia in healthy normoglycemic adults heralds dysglycemia after more than two decades of follow up. Diabetes/Metabolism Research and Reviews 28 (7): 618–624.
Despres JP, Russell AW, O’Moore-Sullivan T, Stolic M, Imbeault, P, Bouchard C (2007). Aging Per Se Does Not Influence Glucose Homeostasis: In vivo and in vitro evidence. Diabetes Care 26 (2): 480–484.
Dikko M (2019). Exploration of gross effect of tamsulosin on glucose and insulin kinetics in rats and humans. A PhD thesis submitted to the Postgraduate School Usmanu Danfodiyo University Sokoto, Nigeria.
Dikko M., Bello SO, Chika A, Mungadi, IA, Sarkingobir Y, Umar AI (2020). Effect of Tamsulosin Use on Plasma Insulin Status in Benign Prostatic Hyperplasia Patients in Sokoto, Nigeria. Journal of Applied Sciences and Environmental Management 24(4):543-548.
Ganiyu AK, Erah OP (2018). Assessment of drug related problems and health-related quality of life in medication management of hypertensive and diabetic patients at two referral health facilities: A prospective study. Nigerian Journal of Pharmaceutical and Applied Science Research 7(2): 104-112.
Isa SA, Ibrahim KG, and Abubakar .(2013).Effect of camel milk supplementation on serum glucose levels,lipid profile, and body weight of alloxan induced diabetic rats. Nigerian Journal of Basic and Applied Sciences 21(3):187-191.
Kang HE, Bae SK, Yoo M, Lee DC, Kim YG, Lee MG. (2009).Interaction between udenafil and tamsulosin in rats: noncompetitive inhibition of tamsulosin metabolism by udenafil via hepatic CYP3A1/2. British Journal of Pharmacology 156:1009-1018.
Katzung BG (2004). Drug receptors and pharmacodynamics. Basic and clinical pharmacology, 9th ed. (McGraw-Hill Medical):17-19.
Lee PG, Halter JB(2017). The pathophysiology of hyperglycemia in older adults: Clinical considerations. Diabetes Care 40 (4): 444–452.
Mangoni AA, Jackson SHD (2004). Age-related changes in pharmacokinetics and pharmacodynamics: Basic principles and practical applications. British Journal of Clinical Pharmacology 57 (1): 6–14.
Marcovecchio ML (2017). Implications of acute and chronic hyperglycemia.U.S.Endocrinology 13(01):1-5.
Muhammad Y, Abubakar N, Musa MS, Wali U, Yeldu MH, Ahmed AY, Ngaski AA, Ahmed MB, Saidu AY, Gulumbe NS (2015). Te effects of Citrulluslanatus seed extracts on Malondialdehyde and serum glucose in streptozocin induced diabetic rats. International Journal of Health Sciences 3(1):356-360.
Muller A (2015). Clinical pharmacology of ADRs.Www.isoponline.org.
Olugbake OA, Adeyemi OC, Ogbonna OC (2019). Pharmacists knowledge and practice of adverse effects of common analgesics in Suru-Lere, Lagos state,Nigeria.Nigerian Journal of Pharmaceutical and Applied Science Research 8(2):114-119.
Riedl MA, Casillas AM (2003). Adverse drug reactions: Types and treatment options. American Family Physician 68(9):1783-1790.
Schatz SN (2015). Adverse drug reactions. CNS/ Pharmacy Practice: 5-26.
Suresha RN, Ashwini V, Pragathi B, Kalabharathi HL, Satish AM, Pushpa VH (2013). The effect of carvedilol on blood glucose levels in normal albino rats. Journal of Clinical and Diagnostic Research 7 (9): 1900–1903.
Siddiqui AA, Siddiqui SA, Suhail A, Siddiqui S, Ahsan I, Sahu K (2013). Diabetes: Mechanism, Pathophysiology and Management-A Review. Insight Medical Publishing. International Journal of Drug Development and Research 5 (2): 1–23.
Szoke E, Shrayyef MZ, Messing S, Woerle HJ, Haeften TW, Van A, Meyer C (2008). Effect of aging on glucose homeostasis: Accelerated deterioration of ?-cell function in individuals with impaired glucose tolerance. Diabetes Care 31 (3): 539–543.
Umar MT, Bello SO, Chika A, Oche, OM (2016). Attitude of nurses and pharmacists on adverse drug reactions reporting in selected hospitals in Sokoto. Journal of Research in Pharmacy Practice 5:219-2121.
Umar RA, Hassan SW, Ladan MJ, Matazu IK, Shehu B, Shehu RA, Muhammed LG, Molabo FI (2010). Adverse effect associated with administration of antiretroviral drugs (Nevirapine, Lamivudine and Stavudine) to albino rats: Implication for management of patients with HIV/AIDS. Asian Journal of Biochemistry 5(3): 181-187.
Wei L, Lai EC, Kao-Yang, Walker BR, MacDonald TM, Andrew R(2019). Incidence of type 2 diabetes mellitus in men receiving steroid 5alpha reductase inhibitors: Population based cohort study. British Medical Journal 365(1204):1-11.