Oral dissolving films of Chlorpheniramine maleate from Wheat Starch/Polymer Blends

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Published: Jul 18, 2020
Keywords:
Oral films, Wheat Starch, Polymer blends, Chlorpheniramine maleate

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M. T. Jaiyeoba
M. A. Odeniyi
J. O. Ayorinde
K. T. Jaiyeoba

Abstract

The aim of this work was to prepare oral dissolving films of Chlorpheniramine maleate using starch/polymer blends.
Formulations of oral disintegrating films of chlorphenarime maleate were prepared from native (NAT), pregelatinised (PGL) and
freeze-dried (FRD) wheat starches blended with hydroxypropylmethyl cellulose (HPMC). The material and rheological
properties of blends of native and modified forms of the native and modified starches and the blended mixtures were
determined. Modified starches were mixed with HPMC to form the starch/polymer blends. Chlorphenirame maleate was
incorporated into the starch-polymer blends by dissolution. Films were obtained through the solvent evaporation method and
evaluated for strength and drug release. The ranking for viscosity for the blends was NAT/HPMC > FRD/HPMC > PGL/HPMC.
Film flexibility ranged from 18 to 41 in the order PGL/HPMC> NAT/HPMC > FRD/HPMC. Drug release for all films was within
10minutes. Flexible oral disintegrating film formulations of chlorpheniramine maleate were obtained from the wheat
starch/HPMC blends.

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How to Cite
Jaiyeoba , M. T., Odeniyi , M. A., Ayorinde , J. O., & Jaiyeoba , K. T. (2020). Oral dissolving films of Chlorpheniramine maleate from Wheat Starch/Polymer Blends. Nigerian Journal of Pharmaceutical and Applied Science Research, 2(1), 25–32. Retrieved from https://nijophasr.net/index.php/nijophasr/article/view/32
Issue
Vol. 2 No. 1 (2013)
Section
Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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