Incidence of Hepatitis C Virus Infection among Students in Public Tertiary Institution in North-Central Nigeria

Main Article Content

Shakirat Iyabo Bello
Patrick Omonua Erah

Abstract

Hepatitis C Virus (HCV) disease is one of the principal health burden in the developing countries especially sub-Saharan Africa. Prevalence rates of 4.3-20% have been reported in various parts of Nigeria. The main objective of this study was to determine the incidence of HCV infection among students in the North-Central Nigeria with the view to identifying risk behavioral factors associated with the incidence. The sera from each of the 202 students enrolled in the study were tested for the presence of anti-HCV using a rapid visual immunoassay kit. A pre-tested questionnaire was used to obtain information on demographic characteristics and risk factors for the virus infection from the studied subjects. Informed consent was sought from the students and ethical approval granted by the institution. The students (mean age: 18.21± 3.57 years; age range: 17–48 years; and mainly females: 57.4%) had HCV incidence rate of 1.98%. Male has a lower risk of being infected with HCV than female counterparts (1:3). There was no significant association between socio-demographic characteristics and HCV positivity. Of all the behavioral risk factors, only those with tattoo showed significant association with HCV (p < 0.009). It is concluded that the incidence of HCV in the study area was low and the use of body tattoo is a major risk factor.

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How to Cite
Bello, S. I. ., & Erah, P. O. (2020). Incidence of Hepatitis C Virus Infection among Students in Public Tertiary Institution in North-Central Nigeria. Nigerian Journal of Pharmaceutical and Applied Science Research, 8(3), 8–14. Retrieved from https://nijophasr.net/index.php/nijophasr/article/view/312
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Articles
Author Biographies

Shakirat Iyabo Bello

Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, Nigeria

Patrick Omonua Erah

Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, University of Benin, Benin City, Nigeria

References

Alao O., Okwori E., Araoye M. (2010). The Sero-Prevalence of hepatitis C virus (HCV) infection among prospective blood donors in Makurdi, Nigeria. The Internet J of Infect Dis. 8:doi: 10.5580/1d2e.

Ayolabi C. I, Taiwo M. A, Omilabu S. A, Abebisi A. O, Fatoba O. M. (2006). Sero-prevalence of hepatitis C virus among blood donors in Lagos, Nigeria. Afric J of Biotec. 5:1944-1946.

Azeez-Akande A., Sarki E. E., Wokedi A., Olabode P. (2010). Seroprevalence and risk factors of Hepatitis C virus in patients and blood donors in Kano, Nigeria, Afri J Clin Exper Microb. 11:170–173.

Chlibek R., Smetana J., Sosovickova R., Gal P., Dite P., Stepanova V., et al. (2017). Prevalence of hepatitis C virus in adult population in the Czech Republic ± time for birth cohort screening. PLoS ONE 12: doi.org/10.1371/.

Coppola N., Alessio L., Lorenzo O., Sagnelli C., Macera M., Sagnelli E., Pisaturo M. (2019). Epidemiology and management of hepatitis C virus infections in immigrant populations. Infect Dis of poverty.17:doi.org/10.1186/s40249-019-0528-6.

Ejiofor S., Emechebe O., Igwe C., Ifeadike O., Ubajaka F. (2017). Hepatitis C virus infection in Nigerians. Nig Med J. 51(4):173-176.

Eke C. B., Ogbodo S. O., Ukoha O. M., Muoneke V. U., Ibekwe R. C., Ikefuna A. N. (2016). Seroprevalence and correlates of hepatitis C virus infection in secondary school children in Enugu, Nigeria. Ann Med Health Sci Res. 6:156-61.

Eze J., Ibeziako N., Ikefuna A., Nwokoye I., Uleanya N., Ilechukwu, G. (2014). Prevalence and risk factors for hepatitis C and human immunodeficiency virus coinfection among children in Enugu, Nigeria. African Journal of Infect. Dis. 8:5-8.

Fattahi M.R., Safarpour A., Sepehrimanesh M., Mohammad KazemHosseini S., Faezeh M. (2015). The prevalence of hepatitis C virus infection and its related risk factors among the rural population of Fars Province, Southern Iran. Hepat. 15: doi: 10.5812/hepatmon.24734.

Godwin I., Abraham O., Peter T., Terkaa T., Vivian H., Michael A. (2013). Prevalence of hepatitis C in Makurdi, North Central Nigeria. J Dent Med Sci. 7:06-10.

Henry B. (2018). Drug pricing and challenges to hepatitis C treatment access. J Health Biomed Law. 14:265–283.

Issar S. K., Ramakrishna B. S., Ramakrishna B., Christopher S., Samuel B.U., John T. J. (2015). Prevalence and presentation of hepatitis C related chronic liver disease in southern India. J. Trop Med Hyg. 98 (3):161–165.

Jemilohun A., Oyelade B., Oiwoh S (2014). Prevalence of hepatitis C virus antibody among undergraduates in Ogbomoso, southwestern Nigeria. Afric J Infect Dis. 8:40 – 43.

Liu C., Li X., Po-lin, Hui Z., Ji-Dong, J, Xiaochun W, Ying-Ru Lo, N. Walsh (2019). Prevalence of hepatitis C virus infection among key populations in China: A systematic review. Inter J Infect Dis. 80: 16-27.

Mahajan R., Midha V., Goyal O., Mehta V., Narang V., Kaur K., Singh A., Singh D., Bhanot R. Sood A. (2018). Clinical profile of hepatitis C virus infection in a developing country: India. J Gastroenterol Hepatol. 33:926-933.

Makuza J. D., Liu C. Y., Ntihabose C. K., Dushimiyimana D., Umuraza S., Nisingizwe M.P., Umutesi J. et al., (2019). Risk factors for viral hepatitis C infection in Rwanda: results from a nationwide screening program. BMC Infect Dis.19: 688. doi: 10.1186/s12879-019-4322-7.

Nakhoul M., Richa C., Jreij A., AbouRached A. (2018). Prevalence of hepatitis B and hepatitis C among intravenous drug abusers in the Lebanese population. J Infect Dev Ctries 12:28S. doi: 10.3855/jidc.10076.

Nwannadi I. A., Alao O. O., Bazuaye G. N., Omoti C. E., Halim N. K. (2012). Seroprevalence of Hepatitis C Virus Antibody in Sickel Cell Anaemia patients in Benin-City, Nigeria. Gomal J Med Sci.10: 1.

Obienu O., Nwokediuko S., Malu A., Lesi F. (2011). Risk factors for hepatitis C virus transmission obscure in Nigerian patients. Gastro Res Pract 939673, 4 pages.

Ojule A. C., Akani C. I., Opurum H. C. (2008). Sero-prevalence of hepatitis C antibodies in pregnant women in Port Harcourt, Nigeria. Port Harcourt Med J. 3(1): 55-61.

Okonko I. O., Ikunga C.V., Anugweje K. C., Okerentugba P.O. (2014). Anti-hepatitis C virus (HCV) antibody detection among fresh undergraduate students in Port Harcourt, Nigeria. Basic Sci Med, 3:26–29.

Olabowale O., Adebayo A (2018). Prevalence of hepatitis C virus antibody among university students in Nigeria. J of Virus Eradicat; 4: 228–229.

Petruzziello A., Marigliano S., Loquercio G., Cozzolino A., Cacciapuoti C. (2016). Global epidemiology of hepatitis C virus infection: An up-date of the distribution and circulation of hepatitis C virus genotypes. World J Gastroenterol. 22:7824–40.

Popping S., Bade D., Boucher C., van der Valk M., El-Sayed M., Sigurour O., Sypsa V., Morgan T., Gamkrelidze A., Mukabatsinda C., Deuffic-Burban S.,Ninburg M., Feld J., Hellard M. (2019). The global campaign to eliminate HBV and HCV infection: International Viral Hepatitis Elimination Meeting and core indicators for development towards the 2030 elimination goals. J Virus Erad. 5:60–66.

Suthar A., Anthony D. (2018). A Public Health Approach to hepatitis c control in low- and middle-income countries. PLoS Med. 12:

doi: 10.1371/journal.pmed.1001795.

Udeze A. O., Bamidele R. A., Okonko I. O., Sule W. F. (2011). Hepatitis C virus (HCV) antibody detection among first year students of University of Ilorin, Ilorin, Nigeria. World J of Med Sci. 6.162-167.

Umego, C.F., Mboto, C.I., Mbim, E.N., Edet, U.O., George, U.E., Tarh, J.E. (2018). Epidemiology of hepatitis B virus infection in south-south, Nigeria: A Review. Port Harcourt Med J. 3(1): 62-69.

Umumararungu E., Ntaganda F., Kagira J. Maina N. (2017). Prevalence of hepatitis C virus infection and its risk factors among patients attending Rwanda Military Hospital, Rwanda. BioMed Res. Intern. doi.org/10.1155/2017/5841272.

World Health Organization (2018). Hepatitis C: Key facts. Available online at:

https://www.who.int/news-room/fact-sheets/detail/hepatitis-c. Accessed on 15/9/2019.

World Health Organization (2019). World hepatitis day. Available online at: https://www.who.int/campaigns/world-hepatitis-day/2019. Accessed on 2/10/2019.

Zenebe Y., Mulu W.,Yimer M., Abera B. (2015). Sero-prevalence and risk factors of hepatitis C virus infection among pregnant women in Bahir Dar city, Northwest Ethiopia: cross sectional study. Pan Afric Med J. 21:158 doi:10.11604/pamj..21.158.6367