Antibacterial Activities of Some Mixed Salicylic Acid- Vitamin C Metal Complexes
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Abstract
The increase of resistant bacteria was found to reduce the efficiency of antimicrobial therapies with the current antibiotics for more efficient drugs for the treatment of infections. Most studies have demonstrated an increase in antimicrobial activity following the interaction of several compounds with metal drug complexes. This study used a methodology adapted for antimicrobial bioassays for plant extracts, in compliance with the standards of the Clinical and Laboratory Standards Institute against Gram-positive and Gram-negative bacteria. Mixed metal drug complexes of Salicylic acid – Vitamin C were prepared and characterised by physico-chemical techniques such as melting point determination, Conductivity measurements and Infrared spectroscopy. The new alternative complexes possessed antimicrobial activity against some isolated organisms: Eurobacter aerogenes, Escherichia coli, Staphylococcus aureus, Serrate marcereus, Bacillus megaterium, Bacillus subtilis, Pseudomonas aeruginosa and Proteus vulgaris. The highest efficacy was shown by CuSO4 complex against Proteus vulgaris (25 mm) while the least inhibition was shown by Salicyclic acid against Pseudomonas Aeroginosa (11 mm). Some of them showed significant activity compared to their parent ligands i.e. NiCl2 against E. coli, and Bacillus subtilis (20 mm and 24 mm); CdSO4 against Serrate marcereus, Bacillus megaterium, Bacillus subtilis and Pseudomonas aeruginosa (24 mm, 20 mm, 21 mm and 22 mm); CuSO4 against E. coli, Serrate marcereus, and Bacillus megaterium (23 mm, and 24 mm); and CoSO4 against E. coli, Staphylococcus aureus and Proteus vulgaris (20 mm).
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