Phytochemical and Antimicrobial Screening of Root Extracts of Carica papaya

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Aremu Olusola Isaac
Abdulganiyu Adekoya

Abstract

Resistance to antimicrobial agents has been on increase in recent time due to a number of factors. There is the need to explore new agents to address the rising failure of some of the existing antimicrobials to therapy. This work is designed to confirm the folklore cla im of the antimicrobial activity of the root extract of the plant Carica papaya. The antimicrobial activity of ethanol extract of male Carica papaya (EMCP), female specie (EFCP) collected at 8.00a.m were tested against some selected bacteria and fungal isolates namely Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae and Staphlococcus a u r eu s and Candida albicans respectively. The antimicrobial activity were evaluated using cup plate diffusion method. The root ext racts of the plant were also screened phytochemically for the presence of secondary metabolites. The two
ext racts, EFCP and EMCP exhibited certain degree of antimicrobial activity from concentration of 62.5mg/ml to 1000mg/ml .The result further indicated some form of simila rity in antimicrobia l activity for both EMCP and EFCP at most concentrations tested. The Extracts of both EMCP and EFCP contains Saponin, Flavonoid, and Tannins in pronounced amount. They also contain Akaloids, anthraquinones, anthocyanide in moderate amount. The antimicrobial activity of EMCP and EFCP was however, lower than that of ciprofloxacin and clotrimazole that were used as reference standards

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Isaac, A. O. ., & Adekoya, A. . (2020). Phytochemical and Antimicrobial Screening of Root Extracts of Carica papaya. Nigerian Journal of Pharmaceutical and Applied Science Research, 5(2), 18–24. Retrieved from https://nijophasr.net/index.php/nijophasr/article/view/127
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Author Biographies

Aremu Olusola Isaac

Department of Pharmaceutics and Industrial pharmacy, Faculty of Phamaceutical Sciences, University of Ilorin, Ilorin.

Abdulganiyu Adekoya

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Olabisi Onabanjo
University, Sagamu Campus

References

Akah, P.A., Oli, A.N., Enwere, N and Gamaliel, K. (1997). Preliminary studies on purgative effect of

Carica papaya root extract. Fitoterapia. 68, 327–

Balandrin, M.F., Klocke, J.A., Wutule, E.S and Bollinger, W.H. (1985). Natural plant chemicals: Sources of industrial and medicinal materials.228, 1154-1160.

Bhathacharga, R.K., Rao, V.M and Oliver, B. (1982). Phenolic content of Carica papaya. J. research Assam Agricultural . 3, 214-217.

Cowan, M.M. (1999). Plant products as antimicrobial agents. Clin Microlbiol Rew. 22, 564-582.

Duke ,J.A .(1984). Borderline herbs CRC press. Bola Raton, F.L.

Dugid, N.R., Marmoin, B.P and Sivon, R.H. (1998).Medicinal potentials of Carica papaya In:A medical microbiology vol. I. Chevchill Livingstone Publishers, pg 236-240

Emeruwa, A.C. (1982) .Antibacterial substance from Carica papaya fruit extracts .J. Nat production. 45(2), 123-127.

Evans WC (2009) Trease and Evans’ Pharmacognosy 16th Edition, Bailliere Tindall. London

Fatope, M.O., Ibrahim, H and Takeda ,Y. (1993). Screening of Higher plants reputed as pesticide. Int. J. Pharmacol. 40 (3), 200-254.

Gill,L.S. (1992). Ethnomedical Uses of Plants in Nigeria, Uniben Press. Benin, Nigeria. Pp 51–54

Gurorrdani, R., Cardenras, M.L and Moulin, J. (1996). Fungicidal activity of latex sap from the fruits of Carica papaya. Mayosa. 39(3), 103-110.

Jones, F.A. (1996). Herbs-useful plants. Their role in history and today. Eur. J .Gastroenterology. 8,1227-1231.

Karunamoorthi, K., Jegajeevanram, K., Vijayalakshmi, J and Embialle,M. (2013). Traditional Medicinal Plants: A Source of Phytotherapeutic Modality in the Resource Constrained Health Care Settings. JEBCAM.18, 67-74.

Karunamoorthi K, Jegajeevanram K, Xavier J, Vijayalakshmi J,Melita L. andTamil. (2012). Traditional Medicinal System – Siddha: An Indigenous Health Practice in the International Perspectives.TANG.; 2:e12.

Lutterodt, G.D., Ismail, A., Basheer, R.H and Baharudin, H.M. (1999).Antimicrobial effects of Psidium guajava extracts as one mechanism of its antidiarrhoea action. Malaysian J.Med. Sci. 6 (2),17-20.

Madrigal ,L., Alberto, S and Rodney, D. (1980). The dependence of crude papain yield on different collection (tapping procedures for papaya latex). J. Sci. for Food Agriculture. 31, 279-285.

Marjorie, M.C (1999). Plant products as antimicrobial agents. Clin Microbiol Rev 12(4), 564-582

Morton, J.F.(1997). Fruit of warm climate creature. Resources system. Inc., pg 336-346

Oloyede, O.I. (2005). Chemical profile of unripe pulp of Carica papaya. Pakistan Journal of Nutrition .4, 379-381.

Owoyele,B.V., Soladoye, A.O and Omopariola, O.A.(2010).Studies on the Analgesic and Antipyretic Activities of Ethanolic Extract of Carica papaya Leaves in Rats In: Medicinal Plants: Phytochemistry, Pharmacology and Therapeutics. Daya Publishing House Delhi - 110 035: 378-384

Satish,S., Raveesha, K.A and Janardhana, G.R.(1999). Antibacterial activity of plant extracts of phytothogenic Xanthomonas campestris pathovars. Let Appl Microbiol. 28, 145-147.

Sherriff, Z.U. (2001). Modern Herbal Therapy for common Ailments. Nature Pharmacy Series (Volume1), Spectrum Books Limited, Ibadan, Nigeria in Association with Safari Books (Export) Limited, United Kingdom, pg 9-88.

Shimoda ,T. (2006). Salivary proteins as a defense against dietary tannis. J. Chem. Ecol.32 (6), 1149-

Sofowora, A. (2008). Medicinal Plants and Traditional Medicine in Africa. Third edition Ibadan: Spectrum Books Limited 4: 66-256.

Wenbebe, C.O.N. (1998). Biological standardization of herbal remedies In, proceeding of 1st international workshop on Herbal medicine products, University of Ibadan, Nov 24

Weisser, R., Asscher, A.W and Winpenny, J. (1966). In vitro reversal of antibiotic resistance by DTA. Nature .219, 1365-1366