Pharmaceutical Characterisation Of Drug Entrapped Cross- Linked Carboxy Methyl Cellulose Nano-Particles
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Abstract
This study was aimed at investigating the physicochemical properties and pharmaceutical applications of drug entrapped cross linked carboxy methyl cellulose nano-particles (CCMC) prepared by solvent evaporation technique after cross linking CMC with acetic anhydride. Three different batches of CCMC nano particles were made with different polymer concentrations and were labeled as SSK10, SSK20 and SSK30. Fulvestrant, a lipophilic drug was used as a candidate drug in this study. Transmission electron microscope (TEM) was used to evaluate the nano-particles morphology, while the zeta potential and the particle size were analyzed with Zetasizer nano ZS using DTS software. The drug loading, in-vitro drug release and percentage entrapped were determined spectrophotometrically.
The results showed that all the nano-particles were spherical, smooth surfaced and pH resistant. There is a linear relationship among the polymer concentration, average nano-particle sizes, and drug entrapped (%) within the nano structure. SSK30 showed the highest drug loading capability and stability in both acidic and alkaline conditions. The novel polymer SSK30, also shows a gradual and consistent release of the entrapped drug molecule devoid of dose dumping. Thus SSK30 offer an alternative, low cost polymeric matrix system suitable for use in the formulation of drug loaded nanoparticles
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