Effect of Ethanolic Leaf Extract of Heinsia crinita (Atama) on the haematological indices and lipid profile in Normoglycemic and Diabetic Albino Wistar Rats.
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Abstract
The effect of ethanolic leaf extract of Heinsia crinita (HC) on the haematological indices and lipid profile of normal and alloxan-induced diabetic rats was studied. Graded doses of the extract (455 and 1365 mg/kg body weight (b.w.) and a reference drug Metformin (Met) were administered to normal rats, diabetic rats at different time points and diabetic rats continuously for 14 days. The antidiabetic activity of HC showed a significant reduction (0>0.05) in blood glucose level in normal rats and alloxan-induced diabetic rats and corresponding diabetic rats treated with HC extract for 2weeks. At the end, the total protein, aminotransferases (ALT and AST), alkaline phosphatase (ALP) were assayed in the blood serum. Total protein and albumin concentration was significantly increased (p<0.05) in the normal rats, the diabetic rats when compared to the diabetic control rats was not significantly (p>0.05) changed in all test groups after treatment. A general significant increase (p<0.05) in AST, ALT, ALP was observed in the activities of the normal and diabetic test groups when compared to the subchronic diabetic control groups. Compared to the diabetic control there was significant increase in AST activities (p<0.05) of diabetic rats administered 455mg/kg b. w. However at a test dose of 1365mg/kg body weight and 100mg/kg Metformin, ALT activities showed a significant difference (p<0.05 for ALT; p<0.05 for Met) relative to diabetic control and 455mg/kg group. The enzyme activity in the 1365mg/kg dose group was significantly different compared to the Met. group. Hence the ethanol leaf extract of Hiensia crinita leaf is not likely to cause liver pathology, and can provide alleviation and protection to the liver with a dose up to 1365 mg/kg b. w.
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